Acetarsol

Bezeichnung:Acetarsol

CAS-Nr97-44-9

Englisch Name:ACETARSONE

CBNumberCB3485369

SummenformelC8H10AsNO5

Molgewicht275.09

MOL-Datei97-44-9.mol

Synonyma

Acetarsol

Acetarsol physikalisch-chemischer Eigenschaften

Schmelzpunkt	220.5°C
Siedepunkt	72.17°C
Dichte	1.0325 g/cm3(Temp: 15 °C)
storage temp.	Store at RT
Löslichkeit	DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
Aggregatzustand	solid
pka	pKa 3.73 (H2O t=26) (Uncertain);7.9 (Uncertain); 9.3(H2O) (Uncertain)
Farbe	Crystalline material
Merck	13,53

Sicherheit

Kennzeichnung gefährlicher	T,N
R-Sätze:	23/25-50/53
S-Sätze:	20/21-28-45-60-61
RIDADR	UN 3465 6.1/PG 2
WGK Germany	3
RTECS-Nr.	CF8400000
HazardClass	6.1(b)
PackingGroup	III
Toxizität	MLD in rabbits, cats (mg/kg): 125-150, 150-175 orally (Anderson, Leake)

Gefahreninformationscode (GHS)

ACETARSONE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/25:Giftig beim Einatmen und Verschlucken.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S20/21:Bei der Arbeit nicht essen, trinken,rauchen.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Originator
Acetarsol ,Cyklo Pharma Chem Pvt. Ltd.
Verwenden
antiprotozoal; diethylamine salt as antiphilitic
Definition
ChEBI: Acetarsol is a member of acetamides and an anilide.
Manufacturing Process
1 part of 4-chloroaniline is dissolved with 2 parts of concentrated hydrochloric acid (specific gravity 1.16) and 10 parts of water, and diazotised in the usual manner. 3 parts of sodium arsenite are introduced into the diazo solution thus obtained, the sodium arsenite being dissolved in 5 parts of water and 1 part of 96% ethanol. The solution is heated slowly to 70°C. When evolution of nitrogene ceased, it is filtered from separated oil and the addition of hydrochloric acid precipitates the 4-chlorophenylarsonic acid, which crystallizes out in the form of white needles.
By action HNO3/H2SO4 on 4-chlorophenylarsonic acid is obtained 4-chloro-3- nitrophenylarsonic acid which is converted at 100°C with 33% aqueous solution of sodium hydroxide to 4-hydroxy-3-nitrophenylarsonic acid. After reduction of NO2 group of 4-hydroxy-3-nitrophenylarsonic acid by the action of Na2S2O3 or Fe/NaOH is obtained 3-amino-4-hydroxyphenylarsonic acid. From 3-amino-4-hydroxyphenylarsonic acid and acetic anhydride is prepared N-acetyl-4-hydroxy-m-arsanilic acid.
Trademarks
190 f;Acetarsolum;Amarson;Arsabott;Auryphan;Chrlich 594;Collarsin;Edoiacolo;Ehrlich 594;F 190;Fluryl;Fourneau 190;Kharophene;Neo-vagex;Pallacid;Trichovan;Vagipurin;Vagisep;Vagival.
Therapeutic Function
Antiprotozoal, Tonic
Weltgesundheitsorganisation (WHO)
Acetarsol, which has antiprotozoal and antitrichomonal activity, has largely been discarded for systemic use because of its potential to cause systemic poisoning. However, topical preparations for vaginal trichomoniasis are still available and it is included in low concentrations (equal to or less than 0.45%) in some medicated toothpastes.
Sicherheitsprofil
Poison by ingestion and intravenous routes. Human systemic effects by ingestion: respiratory system, endocrine system, dermatitis, and fever. Human systemic effects by intravagmal route: hallucinations, dlstorted perceptions, convulsions, nausea or vomiting, decreased urine volume, and fever. Mutation data reported. See also ARSENIC COMPOUNDS. When heated to decomposition it emits very toxic fumes of NOx, and As
läuterung methode
It crystallises from water in colourless prisms. It decomposes slowly on prolonged boiling in H2O or dilute alkalis. The N-propionyl derivative recrystallises from H2O with m 228-229o(dec). [Raiziss & Fisher J Am Chem Soc 48 1323 1926, Hewitt & King J Chem Soc 823 1926, Beilstein 16 I 491, 16 II 521, 16 III 1129.]

ACETARSONE Upstream-Materialien And Downstream Produkte

Acetarsol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

97-44-9, ACETARSONE Verwandte Suche:

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