Alendronic acid

Bezeichnung:Alendronic acid

CAS-Nr66376-36-1

Englisch Name:Alendronic acid

CBNumberCB3380835

SummenformelC4H13NO7P2

Molgewicht249.1

MOL-Datei66376-36-1.mol

Alendronic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	230-235°C
Siedepunkt	616.7±65.0 °C(Predicted)
Dichte	1.857±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
Wasserlöslichkeit	Insoluble in water
Löslichkeit	Aqueous Base (Sparingly), Methanol (Slightly), Water (Very Slightly)
Aggregatzustand	powder to crystal
pka	pK1 2.72 ±0.05; pK2 8.73 ±0.05; pK3 10.5 ±0.1; pK4 11.6 ±0.1 at 25°, (0.1M KCl)
Farbe	White to Light yellow
Merck	14,229
Stabilität	Hygroscopic
EPA chemische Informationen	Phosphonic acid, P,P'-(4-amino-1-hydroxybutylidene)bis- (66376-36-1)

Sicherheit

RIDADR	1759
RTECS-Nr.	SZ6521833
HS Code	2931.90.9051
HazardClass	8
PackingGroup	III
Giftige Stoffe Daten	66376-36-1(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Alendronic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Adronat ,Neopharmed ,Italy
Verwenden
Alendronate acid is an inhibitor of FDPS.
Definition
ChEBI: A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Manufacturing Process
4-Amino-1-hydroxybutylidene-1,1-diphosphonic acid (ABDT).
Orthosphophorous acid (102.7 g; 1.25 moles) is introduced into a 2 liter-flask with condenser, stirrer and dropping funnel, placed on a thermostatized bath; the air is then removed with a nitrogen stream which is continued during all the reaction. The acid is melted by heating the bath to 95°C. When melting is complete, 4-aminobutyric acid (103.3; 1 mole) is added under stirring which is continued till obtaining a doughy fluid. Phosphorous trihalide (176 ml; 2 moles) is added dropwise causing the mixture to boil and evolution of gaseous hydrochloric acid which is damped by means of a suitable trap. The addition rate is adjusted so as to keep a constant reflux for about 60 minutes. When the addition is nearly over, the mixture swells, slowly hardening. Stirring is continued as long as possible, whereafter the mixture is heated for further 3 hours. Without cooling, but removing the bath, water (300 ml) is added, first slowly and then quickly. Heating and stirring are started again. Decolorizing charcoal is added and the mixture is boiled for about 5 minutes, then hotfiltered on paper and the filtrate is refluxed for 6 hours. After cooling is slowly poured in stirred methanol (1500 ml) causing thereby the separation of a white solid which collected and dried (161 g; 64.6%). The structure of ABDT is confirmed by IR spectrum, proton magnetic and nuclear magnetic resonance spectrum and elemental analysis.
The sodium salt of this acid may be prepared by adding of equivalent of sodium hydroxide.
Therapeutic Function
Antiosteoporotic
Hazard
A reproductive hazard.
Clinical Use
Bisphosphonate:
Treatment and prophylaxis of osteoporosis
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Calcium salts: reduced absorption of alendronate.
Stoffwechsel
Alendronate transiently distributes to soft tissues but is then rapidly redistributed to bone or excreted in the urine. There is no evidence that alendronate is metabolised in animals or humans. Following a single intravenous dose of [14C]-alendronate, approximately 50% of the radioactivity was excreted in the urine within 72 hours and little or no radioactivity was recovered in the faeces.

Alendronic acid Upstream-Materialien And Downstream Produkte

Alendronic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

66376-36-1, Alendronic acid Verwandte Suche:

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