SALUBRINAL

Bezeichnung:SALUBRINAL

CAS-Nr405060-95-9

Englisch Name:SALUBRINAL

CBNumberCB3322523

SummenformelC21H17Cl3N4OS

Molgewicht479.81

MOL-Datei405060-95-9.mol

SALUBRINAL physikalisch-chemischer Eigenschaften

Schmelzpunkt	>160°C (dec.)
Dichte	1.474±0.06 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	DMSO: soluble20mg/mL, clear
Aggregatzustand	powder
pka	10.70±0.70(Predicted)
Farbe	white to light yellow to light gray
Wasserlöslichkeit	Insoluble in water.
Sensitive	Light Sensitive
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26
WGK Germany	3

Gefahreninformationscode (GHS)

SALUBRINAL Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Salubrinal is a selective phosphatase inhibitor that prevents dephosphorylation of eukaryotic translation initiation factor 2 subunit α (eIF_2α), protecting PC12 cells from endoplasmic reticulum stress-mediated apoptosis (EC₅₀ = 15 μM). It appears to block the action of protein phosphatase 1 (PP1) on eIF_2α although it does not mimic calyculin A, another PP1-selective inhibitor, in toxicity or phosphorylation pattern. Salubrinal also prevents replication of herpes virus (IC₅₀ = 3 μM), by inhibiting dephosphorylation of eIF_2α. As eIF_2α has a role in bone formation, salubrinal is being studied for its effects in osteoporosis.
Verwenden
Salubrinal is a selective Inhibitor of eIF2α (eukaryotic translation initiation factor 2 α-subunit) dephosphorylation, inhibiting global protein translation. Salubrinal is a specific inhibitor of ER Stress induced apoptosis.
Verwenden
Salubrinal is an endoplasmic reticulum stress blocker that modulates sleep homeostasis and activation of sleep- and wake-regulatory neurons
Verwenden
Salubrinal has been used to study the effect of stress-protective genes and pathways on organism development and lifespan. It has also been used to study the therapeutic potential of salubrinal in methamphetamine induced blood–brain barrier disruption.
Definition
ChEBI: A member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective in ibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha).
Biologische Aktivität
Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2 α ). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC 50 ~ 15 μ M).
Biochem/physiol Actions
Salubrinal is a selective Inhibitor of eIF2α (eukaryotic translation initiation factor 2 α-subunit) dephosphorylation, inhibiting global protein translation. Salubrinal is a specific inhibitor of ER Stress induced apoptosis.
Lager
+4°C
Einzelnachweise
1) Boyce?et al. (2005)?A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress; Science,?307?935 2) Kessel (2006)?Protection of Bcl-2 by salubrinal; Biochem. Biophys. Res. Commun.,?346?1320 3) He?et al. (2013)?Osteoporosis regulation by salubrinal through eFI27alpha; mediated differentiation of osteoclast and osteoblast; Cell. Signal.,?25?552

SALUBRINAL Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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