Chlormethylchlorformiat

Bezeichnung:Chlormethylchlorformiat

CAS-Nr22128-62-7

Englisch Name:Chloromethyl chloroformate

CBNumberCB3271092

SummenformelC2H2Cl2O2

Molgewicht128.94

MOL-Datei22128-62-7.mol

Synonyma

Chlormethylchlorformiat

Chlormethylchlorformiat physikalisch-chemischer Eigenschaften

Schmelzpunkt	<-20°C
Siedepunkt	107-108 °C(lit.)
Dichte	1.449 g/mL at 20 °C
Brechungsindex	n20/D 1.428
Flammpunkt	95°C
storage temp.	2-8°C
Löslichkeit	Chloroform (Soluble), Methanol (Slightly)
Aggregatzustand	clear liquid
Farbe	Colorless to Light yellow to Light orange
Wasserlöslichkeit	Slightly miscible with water.
Sensitive	Moisture Sensitive
BRN	506426
Stabilität	Extremely Moisture Sensitive, Hygroscopic
CAS Datenbank	22128-62-7(CAS DataBase Reference)
EPA chemische Informationen	Carbonochloridic acid, chloromethyl ester (22128-62-7)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23-34
S-Sätze:	26-36/37/39-45
RIDADR	UN 2745 6.1/PG 2
WGK Germany	3
F	10-19-21
HS Code	2915.90.5050
HazardClass	6.1
PackingGroup	II

Gefahreninformationscode (GHS)

Chloromethyl chloroformate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23:Giftig beim Einatmen.
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Chloromethyl chloroformate is Clear Colourless Oil
Verwenden
Chloromethyl chloroformate is used as a reagent in the synthesis of carbamates and carbonates.
Verwenden
Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.
Synthesis Reference(s)
Journal of the American Chemical Society, 106, p. 1808, 1984 DOI: 10.1021/ja00318a042
Allgemeine Beschreibung
Chloromethyl chloroformate is a colorless liquid with a penetrating, irritating odor. Denser than water. Contact may irritate skin, eyes and mucous membranes. Toxic by ingestion, inhalation and skin absorption. Used to make other chemicals.
Air & Water Reaktionen
Reacts with moisture in air to generate heat and hydrochloric acid fumes [Merck, 11th ed., 1989]. Reacts with water.
Reaktivität anzeigen
CHLOROMETHYLCHLOROFORMATE is water reactive. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Brandgefahr
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Vapors may accumulate in confined areas (basement, tanks, hopper/tank cars etc.). Substance will react with water (some violently), releasing corrosive and/or toxic gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Chloromethyl chloroformate Upstream-Materialien And Downstream Produkte

22128-62-7, Chloromethyl chloroformate Verwandte Suche:

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