Pyrviniumembonat

Bezeichnung:Pyrviniumembonat

CAS-Nr3546-41-6

Englisch Name:PYRVINIUM PAMOATE

CBNumberCB3249600

SummenformelC75H70N6O6

Molgewicht1151.39

MOL-Datei3546-41-6.mol

Synonyma

Pyrviniumembonat

Pyrviniumembonat physikalisch-chemischer Eigenschaften

Schmelzpunkt	210-215° (softens at 190°)
Siedepunkt	829.27°C (rough estimate)
Dichte	1.0104 (rough estimate)
Brechungsindex	1.6400 (estimate)
storage temp.	2-8°C
Löslichkeit	DMSO: >10mg/mL
Aggregatzustand	powder
Farbe	red
EPA chemische Informationen	Pyrvinium pamoate (3546-41-6)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-36/37/38-40
S-Sätze:	26-36
WGK Germany	3
HS Code	2933492250

Gefahreninformationscode (GHS)

PYRVINIUM PAMOATE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Pyrvinium is a tasteless, odorless, bright orange to black, crystalline solid. It is insoluble in water or ether, slightly soluble in chloroform, and soluble in glacial acetic acid.
Verwenden
anthelmintic
Verwenden
Pyrvinium Pamoate is a potent noncompetitive inhibitor of the androgen receptor, with the application towards prostate cancer treatment. Antihelmintic.
Definition
ChEBI: Pyrvinium pamoate is a naphthoic acid. It has a role as an anticoronaviral agent.
Indications
The cation is the active part of the compound. Pyrvinium is used against pinworms (Enterobius).
Trademarks
Povan (Parke-Davis).
Allgemeine Beschreibung
Odorless bright orange or orange-red to brownish red or almost black fluffy powder. Melting point 210-215°C. Insoluble in water. Tasteless.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
PYRVINIUM PAMOATE is light sensitive. Incompatible with strong oxidizing agents, strong acids and bases .
Brandgefahr
Flash point data for PYRVINIUM PAMOATE are not available; however, PYRVINIUM PAMOATE is probably combustible.
Biochem/physiol Actions
Pyrvinium pamoate is a potent androgen receptor inhibitor. Androgen receptors (ARs) are nuclear hormone receptors/transcription factors that reside in the cytoplasm and activated by testosterone and dihydrotestosterone. AR inhibitors have potential therapeutic benefit in prostate cancer; competitive inhibitors and chemical castration methods have been discovered, but both therapies have undesirable side effects and/or resistance potential. A screen for non-competitive inhibitors was performed, resulting in the discovery of pyrvinium as an AR inhibitor. In comparison to competitive inhibitors, this compound does not bind to the ligand-binding domain of AR or block DNA occupancy by AR, but it inhibits AR-dependent gene expression via a distinct signaling mechanism. It is more potent than classical competitive AR antagonists and exhibits synergy with other AR inhibitors.
Nebenwirkungen
Occasional adverse reactions are blood dyscrasia and folic acid deficiency. Rare adverse reactions are rash, vomiting, convulsion, shock, photosensitivity, and headache.

Pyrviniumembonat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

3546-41-6, PYRVINIUM PAMOATE Verwandte Suche:

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