2-Naphthoesure

Bezeichnung:2-Naphthoesure

Englisch Name:2-Naphthoic acid

CBNumberCB2363217

SummenformelC11H8O2

Molgewicht172.18

Synonyma

2-Naphthoesure

2-Naphthoesure physikalisch-chemischer Eigenschaften

Schmelzpunkt	185-187 °C(lit.)
Siedepunkt	300 °C
Dichte	1.08
Brechungsindex	1.5520 (estimate)
Flammpunkt	205 °C
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	alcohol: soluble
pka	4.17(at 25℃)
Aggregatzustand	Powder
Farbe	White to beige
PH	4.5 (H2O, 20℃)
Wasserlöslichkeit	<0.5 g/L (20 C)
Merck	14,6382
BRN	972039
InChIKey	UOBYKYZJUGYBDK-UHFFFAOYSA-N
CAS Datenbank	93-09-4(CAS DataBase Reference)
NIST chemische Informationen	2-Naphthalenecarboxylic acid(93-09-4)
EPA chemische Informationen	2-Naphthalenecarboxylic acid (93-09-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-24/25-36/373/39
WGK Germany	2
RTECS-Nr.	QL1050000
TSCA	Yes
HS Code	29163900

Gefahreninformationscode (GHS)

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Colorless solid
Verwenden
2-Naphthoic acid is an unprotected acid undergoes lithiation, e.g. with s-BuLi, by stereospecific 1,4-addition, providing a facile route to 1,2,2-trisubstituted 1,2-dihydronaphthalenes. It is also used as an intermediate in organic synthesis. The fluorescence spectra and electronic absorption of 2-naphthoic acid was studied.
Definition
ChEBI: 2-naphthoic acid is a naphthoic acid that is naphthalene carrying a carboxy group at position 2. It has a role as a xenobiotic metabolite and a mouse metabolite. It is a conjugate acid of a 2-naphthoate.
Allgemeine Beschreibung
2-Naphthoic acid (NPA) is a noncompetitive N-methyl-D-aspartate (NMDA) receptor inhibitor. The fluorescence spectra and electronic absorption of 2-naphthoic acid was studied.
läuterung methode
Crystallise the acid from EtOH (4mL/g), aqueous 50% EtOH or Me2CO (m 185-186o). Dry it at 100o. The acid chloride has m 52-52o (from *C6H6/pet ether) and b 160-162o/11mm [Hersberg & Carson Org Synth Coll Vol III 629 1955], the amide has m 192o (from EtOH), and the N-Methyl amide has m 109-109.5o (form *C6H6). [Beilstein 9 H 656, 9 III 3174, 9 IV 2402.]