Cloquintocet-mexyl

Bezeichnung:Cloquintocet-mexyl

CAS-Nr99607-70-2

Englisch Name:Cloquintocet-mexyl

CBNumberCB3243431

SummenformelC18H22ClNO3

Molgewicht335.83

MOL-Datei99607-70-2.mol

Cloquintocet-mexyl physikalisch-chemischer Eigenschaften

Schmelzpunkt	69°
Siedepunkt	448.4±30.0 °C(Predicted)
Dichte	1.163±0.06 g/cm3(Predicted)
Dampfdruck	0-54.4Pa at 25-185.9℃
storage temp.	Sealed in dry,2-8°C
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
Aggregatzustand	Solid
pka	1.94±0.29(Predicted)
Farbe	White to Off-White
Merck	14,2401
Stabilität	Stable. Incompatible with strong oxidizing agents.
LogP	5.2-5.24 at 25℃ and pH5-9.1
Oberflächenspannung	56.8-57.2mN/m at 590μg/L and 20℃
Dissoziationskonstante	3.55 at 20℃
CAS Datenbank	99607-70-2(CAS DataBase Reference)
EPA chemische Informationen	Cloquintocet-mexyl (99607-70-2)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	43
S-Sätze:	36/37
RIDADR	UN 3077
WGK Germany	2
RTECS-Nr.	AG1265000
HS Code	2933.49.3000
Toxizität	LD50 in rats (mg/kg): >2000 orally; >2000 dermally; LC50 (4 hr) in rats: >935 mg/m3 by inhalation (Amrein)

Gefahreninformationscode (GHS)

Cloquintocet-mexyl Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Cloquintocet-mexyl is a colourless crystalline herbicide safener. It is categorized as Class III toxin.
Chemische Eigenschaften
beige solid
Verwenden
Cloquintocet-mexyl is a herbicide. It is used to control coarse annual grass of the family poaceae (gramineae). lt was developed by the swiss ciba geigy in the 1980s and the patent has expired.
Verwenden
Cloquintocet-mexyl is used as a herbicide.
Definition
ChEBI: Heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate is a member of the class of quinolines that is quinoline which is substituted by a chloro group at position 5 and by a 2-[(heptan-2-yl)oxy]-2-oxoethoxy group at position 8. It is an aromatic ether, an organochlorine compound, a member of quinolines and a carboxylic ester.
Landwirtschaftliche Anwendung
Cloquintocet-mexyl is a safener that can be used in conjunction with various herbicides to reduce phytotoxicity to crops. Though effective as a safener, the manufacture, storage, and use of cloquintocet-mexyl containing products can present challenges owing to its sensitivity to water and its low melting temperature (i.e., 61-69° C. for technical material). When products containing cloquintocet-mexyl are prepared, stored, or used in the presence of water, cloquin tocet-mexyl can undergo hydrolysis to form cloquintocet acid, and/or form a needle-shaped, crystalline hydrate that can, lead to clogged spray nozzles during spray applications and/or possibly increased levels of crop phytotoxicity.
Carcinogenicity
In accordance with the EPA Proposed EPA Weight-of-the-Evidence Categories, August 1999, the HIARC classified cloquintocet-mexyl as "not likely to be a human carcinogen." Carcinogenicity studies in rats and mice did not show increased incidence of spontaneous tumor formation. With negative mutagenic test battery, it is suggested that cloquintocet-mexyl (CGA 185072) is not likely to be a human carcinogen.
Stoffwechsel
Metabolism studies in rats indicated that approximately 40% of the administered dose of cloquintocet-mexyl was absorbed through the gastrointestinal tract and subsequently excreted via the urine. Fecal excretion accounted for approximately 60% of the administered dose. The chemical was rapidly eliminated (more than 80% of the administered dose) via feces and urine within 48 hours post-dosing. Sex, dosing regime, and dose levels had little effect on the excretion pattern. Excretion patterns were similar between the biliary cannulated and non-cannulated animals indicating that there was no enterohepatic circulation of the chemical. Three days after administration, tissue radioactivity accounted for less than 0.3% of the administered dose (or was non-detectable) and was not detectable in the expired air. At day three post-dosing, most tissue residues of radioactivity were below the limit of detection. The major metabolic pathway of cloquintocet-mexyl was ester hydrolysis to yield 5-chloro-8-quinolinoxy acetic acid, the major metabolite in the fecal and urinary pools.
Toxicity evaluation
Cloquintocet-mexyl has a low order of acute oral, dermal, and inhalation toxicity. It is slightly irritating to the eyes and non-irritating to the skin. Cloquintocet-mexyl is a skin sensitizer. The chemical is not genotoxic and is not a reproductive and developmental toxicant. There is no evidence of neurotoxicity in the available studies. Cloquintocet-mexyl is classified as “not likely to be a human carcinogen.” The main metabolite for cloquintocet-mexyl is 5-chloro-8-quin-linoxyacetic acid, and testing on the metabolite is part of the toxicology database for cloquintocet-mexyl.

Cloquintocet-mexyl Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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