Methyltrienolone

Bezeichnung:Methyltrienolone

CAS-Nr965-93-5

Englisch Name:Methyltrienolone

CBNumberCB3221633

SummenformelC19H24O2

Molgewicht284.39

MOL-Datei965-93-5.mol

Methyltrienolone physikalisch-chemischer Eigenschaften

Schmelzpunkt	170°
alpha	D20 -58.7° (c = 0.5 in ethanol)
Siedepunkt	485.9±45.0 °C(Predicted)
Dichte	1.17±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: ≥10mg/mL
pka	14.79±0.40(Predicted)
Aggregatzustand	powder
Farbe	light yellow to yellow
Optische Aktivität	[α]/D -48 to -68°
InChI	InChI=1/C19H24O2/c1-18-9-7-15-14-6-4-13(20)11-12(14)3-5-16(15)17(18)8-10-19(18,2)21/h7,9,11,16-17,21H,3-6,8,10H2,1-2H3/t16-,17+,18+,19+/s3
InChIKey	CCCIJQPRIXGQOE-XWSJACJDSA-N
SMILES	[C@@]12([H])CC[C@@](O)(C)[C@@]1(C)C=CC1=C3CCC(=O)C=C3CC[C@@]21[H] \|&1:0,4,7,21,r\|
CAS Datenbank	965-93-5(CAS DataBase Reference)

Sicherheit

WGK Germany	3
DEA Controlled Substances	CSCN: 4000 CSA SCH: Schedule III NARC: No

Gefahreninformationscode (GHS)

Methyltrienolone Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Methyltrienolone, also called metribolone, is an orally active anabolic-androgen steroid being a 17α-alkylated nandrolone (19-nortestosterone) derivative. It is not sold as a prescription drug or a dietary supplement due to its strong androgenic side effects and liver toxicity. However, it is often used as the reference point for in vitro biological activity for biochemical studies. It can bind strongly to the androgen receptor and can be used as an affinity label of the androgen receptor in the prostate and prostatic tumors.
Chemische Eigenschaften
Pale Yellow Solid
Verwenden
Methyltrienolone is a synthetic derivative of testosterone that is used in the medical field as an androgen and anabolic agent. It has been used to treat breast cancer, prostate cancer, and other cancers that are sensitive to hormones.
Definition
ChEBI: Methyltrienolone, also known as 7beta-hydroxy-17-methylestra-4,9,11-trien-3-one, is a synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors. It has a role as an androgen. It is an anabolic androgenic steroid, a 17beta-hydroxy steroid and a 3-oxo steroid. It derives from a hydride of an estrane.
Biochem/physiol Actions
Androgen receptors (ARs) are nuclear hormone receptors/transcription factors. R1881, also known as methyltrienolone, is a synthetic androgen. It is the gold standard AR agonist.
Einzelnachweise
https://en.wikipedia.org/wiki/Metribolone
https://www.drugbank.ca/drugs/DB02998
https://pubchem.ncbi.nlm.nih.gov/compound/Methyltrienolone
Kazlauskas R. (2010) Designer Steroids. In: Thieme D., Hemmersbach P. (eds) Doping in Sports: Biochemical Principles, Effects and Analysis. Handbook of Experimental Pharmacology, vol 195. Springer, Berlin, Heidelberg

Methyltrienolone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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