Quipazine

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Quipazine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  antineoplastic

• Definition

  ChEBI: 2-(1-piperazinyl)quinoline is a member of pyridines and a member of piperazines.

• Synthese

  

  110-85-0

  

  612-62-4

  

  4774-24-7

  Step 1: Piperazine (10.20 g, 2.45 mmol) was dissolved in 15 mL of isopropanol in a dry round-bottomed flask under nitrogen protection. Subsequently, 2-chloroquinoline (0.20 g, 1.2 mmol) was added and the reaction mixture was heated and stirred at reflux for 24 hours. After completion of the reaction, water was added to the mixture and extracted with ethyl acetate. The organic layers were combined, washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product obtained was purified by silica gel column chromatography with eluent ratio of dichloromethane:methanol=4:1 to afford the target compound 2-(piperazin-1-yl)quinoline in 36% yield.

• in vivo

  Quipazine (2.5, 5 and 7.5 mg/kg, one dose for once; i.p.) affects dietary self-selection of different macronutrient diets in male and female rats^[1].

• Einzelnachweise

  [1] Patent: EP1724267, 2006, A1. Location in patent: Page/Page column 35; 68
  [2] Journal of Medicinal Chemistry, 2010, vol. 53, # 21, p. 7549 - 7563
  [3] Journal of Pharmaceutical Sciences, 1992, vol. 81, # 1, p. 99 - 103
  [4] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 10, p. 1314 - 1320
  [5] Patent: WO2004/46124, 2004, A1. Location in patent: Page 41

Quipazine Upstream-Materialien And Downstream Produkte

Quipazine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(109)Suppliers

4774-24-7, Quipazine Verwandte Suche: