1-(10-(3-(4-(2-Hydroxyethyl)-1-piperazinyl)propyl)-10H-pheno-thiazin-2-yl)ethanon,(Z)-2-butendioat(1:2)

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H319：Verursacht schwere Augenreizung.

• Sicherheit

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

ACETOPHENAZINE MALEATE (200 MG) Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Tindal ,Schering ,US ,1961

• Verwenden

  Antipsychotic.

• Definition

  ChEBI: A maleate salt obtained by combining acetophenazine with two molar equivalents of maleic acid.

• Manufacturing Process

  The requisite intermediate, 10-(3-chloropropyl)-2-acetylphenothiazineis prepared as follows: To a suspension of sodium amide (from 3 grams of sodium) in 300 ml of liquid ammonia is added 30 grams of 2- acetylphenothiazine. After stirring for one hour, there is added 19 grams of 1- bromo-3-chloropropane. The ammonia is allowed to evaporate and the residue is diluted with 200 ml of water. The mixture is extracted with ether and the ether solution is dried over anhydrous sodium sulfate, filtered and concentrated.
  The residue consists of crude 10-(3-chloropropy1)-2-acetylphenothiazine as a viscous oil and is used in the next step without further purification. The crude base obtained from the reaction of 10-(3-chloropropyl)-2-acetylphenothiazine with 1-(2-hydroxyethyl)piperazine is purified by conversion to its dimaleate salt, MP 167-168.5°C from ethanol.

• Trademarks

  Tindal (Schering).

• Therapeutic Function

  Tranquilizer

• Sicherheitsprofil

  Poison by ingestion, intraperitoneal,and intravenous routes. Severe eye irritant.

ACETOPHENAZINE MALEATE (200 MG) Upstream-Materialien And Downstream Produkte

1-(10-(3-(4-(2-Hydroxyethyl)-1-piperazinyl)propyl)-10H-pheno-thiazin-2-yl)ethanon,(Z)-2-butendioat(1:2) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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