2-Chlor-10-(3-(4-methyl-1-pipera-zinyl)propyl)-10H-phenothiazin

Bezeichnung:2-Chlor-10-(3-(4-methyl-1-pipera-zinyl)propyl)-10H-phenothiazin

CAS-Nr58-38-8

Englisch Name:Prochlorperazine

CBNumberCB7352500

SummenformelC20H24ClN3S

Molgewicht373.94

MOL-Datei58-38-8.mol

Synonyma

Prochlorperazin

2-Chlor-10-(3-(4-methyl-1-pipera-zinyl)propyl)-10H-phenothiazin

2-Chlor-10-(3-(4-methyl-1-pipera-zinyl)propyl)-10H-phenothiazin physikalisch-chemischer Eigenschaften

Schmelzpunkt	228 °C
Siedepunkt	260-275 °C(Press: 2 Torr)
Dichte	1.1679 (rough estimate)
Brechungsindex	1.6000 (estimate)
storage temp.	Refrigerator
Löslichkeit	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	pKa 8.1(H2O,t =24±1,I undefined) (Uncertain)
Farbe	White to Yellow
Wasserlöslichkeit	14.96mg/L(24 ºC)
BCS Class	2
CAS Datenbank	58-38-8(CAS DataBase Reference)
NIST chemische Informationen	Prochlorperazine(58-38-8)

Sicherheit

Giftige Stoffe Daten	58-38-8(Hazardous Substances Data)
Toxizität	LD50 oral in rat: 1800mg/kg

Prochlorperazine Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
antiemetic, antipsychotic, treatment of vertigo
Verwenden
Prochlorperazine is antiemetic, antipsychotic; used in treatment of vertigo.
Definition
ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
Trademarks
Compazine (GlaxoSmithKline).
Clinical Use

Nausea and vomiting
Labyrinthine disorders
Psychoses
Severe anxiety
Sicherheitsprofil
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: headache, blood pressure elevation. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl-.
Veterinary Drugs and Treatments
Prochlorperazine as a single agent is used in dogs and cats as an antiemetic. The only approved products for animals are combination products containing prochlorperazine, isopropamide, with or without neomycin (Darbazine?, Neo-Darbazine?—SKB Labs) which are no longer marketed in the USA. The approved indications for these products include: vomiting, non-specific gastroenteritis, drug induced diarrhea, infectious diarrhea, spastic colitis, and motion sickness in dogs and cats (injectable product only).
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids; increased risk of ventricular arrhythmias with methadone.
Anti-arrhythmics increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval, e.g. procainamide, disopyramide, dronedarone and amiodarone - avoid with amiodarone and dronedarone.
Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid.
Antidepressants: increase concentrations and additive antimuscarinic effects, notably with tricyclics; increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine.
Antiepileptics: antagonised (convulsive threshold lowered).
Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone.
Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid.
Anxiolytics and hypnotics: increased sedative effects.
Atomoxetine: increased risk of ventricular arrhythmias.
Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol.
Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide.
Desferrioxamine: avoid concomitant use.
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
Pentamidine: increased risk of ventricular arrhythmias.
Stoffwechsel
Prochlorperazine undergoes extensive first pass metabolism in the gut wall. It is also extensively metabolised in the liver and is excreted in the urine and bile. The metabolites are inactive.

Prochlorperazine Upstream-Materialien And Downstream Produkte

2-Chlor-10-(3-(4-methyl-1-pipera-zinyl)propyl)-10H-phenothiazin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

58-38-8, Prochlorperazine Verwandte Suche:

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