Proglumid

Bezeichnung:Proglumid

CAS-Nr6620-60-6

Englisch Name:Proglumide

CBNumberCB2479493

SummenformelC18H26N2O4

Molgewicht334.41

MOL-Datei6620-60-6.mol

Synonyma

Proglumid

Proglumid physikalisch-chemischer Eigenschaften

Schmelzpunkt	148-150°C
Siedepunkt	471.21°C (rough estimate)
Dichte	1.1944 (rough estimate)
Brechungsindex	1.5700 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	4.51±0.10(Predicted)
Farbe	Crystals
CAS Datenbank	6620-60-6(CAS DataBase Reference)
EPA chemische Informationen	Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo- (6620-60-6)

Sicherheit

Toxizität

LD50 in mice (mg/kg): 2211-2649 i.v.; 7350-8861 orally (Rovati)

Gefahreninformationscode (GHS)

Proglumide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.
Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.
Chemische Eigenschaften
White Solid
Verwenden
Anticholinergic.
Definition
ChEBI: Proglumide is a racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs. It has a role as a drug metabolite, a xenobiotic metabolite, a cholinergic antagonist, an anti-ulcer drug, a cholecystokinin antagonist, a gastrointestinal drug, a delta-opioid receptor agonist and an opioid analgesic. It contains a (R)-proglumide and a (S)-proglumide.
Trademarks
Nulsa (Wallace).
Nebenwirkungen
An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs, and can prevent or even reverse the development of tolerance to opioid drugs. This can make it a useful adjuvant treatment to use alongside opioid drugs in the treatment of chronic pain conditions such as cancer, where opioid analgesics may be required for long periods and development of tolerance reduces clinical efficacy of these drugs.
Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its analgesic effects.
Sicherheitsprofil
Moderately toxic by severalroutes. An experimental teratogen. When heated todecomposition it emits toxic fumes of NOx.
Enzyminhibitor
This anticholinergic agent (FWfree-acid = 334.42 g/mol; CAS 6620-60-6), also known as DL-4-benzamido-N,N-dipropylglutaramic acid and 4- (benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid, is a cholecystokinin receptor antagonist. Proglumide A also exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It finds use clinically as a therapy for gastrointestinal ulcers. Target(s): cholecystokinin receptor; gastrin receptor.

Proglumide Upstream-Materialien And Downstream Produkte

Proglumid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

6620-60-6, Proglumide Verwandte Suche:

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