GAMMA-LINOLENIC ACID METHYL ESTER

Bezeichnung:GAMMA-LINOLENIC ACID METHYL ESTER

CAS-Nr16326-32-2

Englisch Name:GAMMA-LINOLENIC ACID METHYL ESTER

CBNumberCB2454755

SummenformelC19H32O2

Molgewicht292.46

MOL-Datei16326-32-2.mol

GAMMA-LINOLENIC ACID METHYL ESTER physikalisch-chemischer Eigenschaften

Siedepunkt	162 °C0.5 mm Hg(lit.)
Dichte	0.9019 g/cm3
Brechungsindex	n20/D 1.476(lit.)
Flammpunkt	62 °C
storage temp.	-20°C
Löslichkeit	≤100mg/ml in DMSO;100mg/ml in dimethyl formamide
Aggregatzustand	Liquid

Sicherheit

Kennzeichnung gefährlicher	F
R-Sätze:	11
S-Sätze:	16
RIDADR	UN 1993 / PGIII
WGK Germany	3
F	8-10-23

Gefahreninformationscode (GHS)

GAMMA-LINOLENIC ACID METHYL ESTER Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Polyunsaturated fatty acids (PUFAs) are essential nutrients that show distinct deficiency syndromes when not present in adequate amounts in the diet. γ-Linolenic Acid methyl ester (Methyl GLA) is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B₄ (LTB₄) receptor antagonist, inhibiting [³H]-LTB₄ binding to porcine neutrophil membranes with a K_i of 1 μM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB₄-induced bronchoconstriction.
Verwenden
Methyl γ-linolenate may be used as an analytical standard for the determination of aldehydes such as pentanal and hexanal via peroxidation, further analyzed by gas chromatography technique. It may also be used as an analytical reference standard for the quantification of the analyte in serum lipid extract and Arthrospira (Spirulina) platensis using the gas-chromatography technique.
Definition
ChEBI: Methyl gamma-linolenate is a fatty acid methyl ester obtained from the formal condensation of methanol and gamma-linolenic acid. It has a role as a bacterial metabolite, an apoptosis inducer, an antineoplastic agent and an antibacterial agent. It is functionally related to a gamma-linolenic acid.
Biochem/physiol Actions
Methyl γ-linolenate (C18:6,9,12) differs from methyl α-linolenate (C18:9,12,15) in the positions of the double bonds. Methyl γ-linolenate may be used in nutritional studies regarding weight regain and as a possible tumor suppression agent.
in vitro
γ-linolenic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of gla-containing diets and dietary supplements. gla was identified as an ω-6 fatty acid which could be elongated to arachidonic acid for endogenous eicosanoid synthesis. gla was found to be a weak leukotriene b4 (ltb4) receptor antagonist, which was able to inhibit [3h]-ltb4 binding to porcine neutrophil membranes with a ki of 1 μm [1].
in vivo
in an in-vivo model of ltb4-induced bronchoconstriction, ricinelaidic acid andγ-linolenic acid methyl ester at a 1 mg/kg i.v. dose could result in 46% and 53% inhibition, respectively, indicating that essential fatty acids are ltb4 receptor antagonists, which may account in part for their reported anti-inflammatory activities [1].
Einzelnachweise
[1] yagaloff, k. a.,franco, l.,simko, b., et al. essential fatty acids are antagonists of the leukotriene b4 receptor. prostaglandins, leukotrienes and essential fatty acids 52, 293-297 (1995).

GAMMA-LINOLENIC ACID METHYL ESTER Upstream-Materialien And Downstream Produkte

GAMMA-LINOLENIC ACID METHYL ESTER Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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