Nonactin

Bezeichnung:Nonactin

CAS-Nr6833-84-7

Englisch Name:NONACTIN

CBNumberCB2424675

SummenformelC40H64O12

Molgewicht736.93

MOL-Datei6833-84-7.mol

Synonyma

Nonactin

Nonactin physikalisch-chemischer Eigenschaften

Schmelzpunkt	147-148°
Siedepunkt	890.6±65.0 °C(Predicted)
Dichte	1.11-1.15 g/cm3
storage temp.	2-8°C
Löslichkeit	chloroform: soluble10mg/mL
Aggregatzustand	White to off-white crystalline solid.
Farbe	white to faint yellow
Sensitive	Moisture Sensitive
Merck	13,6709
BRN	76434
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

Sicherheit

Kennzeichnung gefährlicher	Xi
S-Sätze:	22-24/25
WGK Germany	3
RTECS-Nr.	RH1685000
F	10-21
HS Code	29321900
Toxizität	LD50 intravenous in mouse: 246mg/kg

Gefahreninformationscode (GHS)

NONACTIN Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Nonactin (6833-84-7) is a monovalent cation ionophore with high selectivity for NH4+ and K+ .1 Upregulates levels of mitochondrial stress proteins HSP58 and GRP75.2 Nonactin abolishes mitochondrial membrane potential.3
Chemische Eigenschaften
Light yellow powder
Verwenden
Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purified to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium.
Verwenden
Nonactin is an ionophore antiobiotic that selectively binds K+?and NH4+.
Definition
ChEBI: Nonactin is a macrotetrolide.
Biologische Aktivität
Monovalent cation ionophore that displays selectivity for K + and NH 4 + (K + = NH 4 + > Na + > Mg 2+ > Li + >> Ca 2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.
läuterung methode
This macrotetrolide antibiotic crystallises from MeOH as colourless needles and is dried at 90o/20hours/high vacuum. [Cordaz et al. Helv Chim Acta 38 1445 1955, crystal structure: Dobler Helv Chim Acta 55 1371 1972, Gambos et al. Tetrahedron Lett 3391 1975, Beilstein 19/12 V 751.]
Einzelnachweise
1) Garcia et al. (2003), Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occulded in EVA membrane; J. Pham. Biomed. Anal., 31 11 2) Mizzen et al. (1989), Identification, characterization and purification of two mammalian stress proteins present in mitochondria, grp 75, a member of the hsp 70 family and hsp 58, a homolog of the bacterial groEL protein; J. Biol. Chem., 264 20664 3) Dudani et al. (1990), Effects of antimitotic and antimitochondrial agents on the cellular distribution of microtubules and mitochondria; Cytobios, 63 95

Nonactin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

6833-84-7, NONACTIN Verwandte Suche:

Send Inquriy