Hydrogen[4-[4-(p-ethoxyanilino)-4'-[ethyl(m-sulfonatobenzyl)amino]-2'-methylbenzhydrylen]-3-methylcyclohexa-2,5-dien-1-yliden](ethyl)(m-sulfonatobenzyl)ammonium, Mononatriumsalz

Bezeichnung:Hydrogen[4-[4-(p-ethoxyanilino)-4'-[ethyl(m-sulfonatobenzyl)amino]-2'-methylbenzhydrylen]-3-methylcyclohexa-2,5-dien-1-yliden](ethyl)(m-sulfonatobenzyl)ammonium, Mononatriumsalz

CAS-Nr6104-58-1

Englisch Name:Acid Blue 90

CBNumberCB2275235

SummenformelC47H48N3NaO7S2

Molgewicht854.02

MOL-Datei6104-58-1.mol

Synonyma

Hydrogen[4-[4-(p-ethoxyanilino)-4'-[ethyl(m-sulfonatobenzyl)amino]-2'-methylbenzhydrylen]-3-methylcyclohexa-2,5-dien-1-yliden](ethyl)(m-sulfonatobenzyl)ammonium, Mononatriumsalz

Hydrogen[4-[4-(p-ethoxyanilino)-4'-[ethyl(m-sulfonatobenzyl)amino]-2'-methylbenzhydrylen]-3-methylcyclohexa-2,5-dien-1-yliden](ethyl)(m-sulfonatobenzyl)ammonium, Mononatriumsalz physikalisch-chemischer Eigenschaften

Schmelzpunkt	100 °C
Dichte	1.274[at 20℃]
Dampfdruck	0.093Pa at 20℃
Flammpunkt	11 °C
storage temp.	2-8°C
Löslichkeit	H2O: soluble1mg/mL
Aggregatzustand	Solid
Colour Index	42655
Farbe	Dark blue-violet-brown
Wasserlöslichkeit	Soluble in water (50 mg/ml) and ethanol (40 mg/ml).
BRN	5230822
Stabilität	Light Sensitive
InChIKey	JFNOCRSXNFZMNT-UHFFFAOYSA-M
LogP	-2.55 at 20℃
CAS Datenbank	6104-58-1(CAS DataBase Reference)
EPA chemische Informationen	C.I. Acid Blue 90 (6104-58-1)

Sicherheit

R-Sätze:
S-Sätze:
WGK Germany	3
TSCA	Yes
HS Code	32041200

Gefahreninformationscode (GHS)

Acid Blue 90 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R35:Verursacht schwere Verätzungen.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S9:Behälter an einem gut gelüfteten Ort aufbewahren.
S7:Behälter dicht geschlossen halten.
Chemische Eigenschaften
dark blue-violet-brown crystalline powder
Verwenden
Brilliant Blue G is used in analytical biochemistry dye and as a P2X7 antagonist. It is also used in protein staining following gel electrophoresis. It is used to prepare the protein reagent for the determination of protein content of the collagenase enzyme isolated from fish waste. It may be employed as stain for the internal limiting membrane (ILM) for the macular hole (MH) and epiretinal membrane (ERM) surgery. It is useful for SDS gels as it readily stains proteins with minimal background color. Protein bands can be visualized during staining. It has been used in the Bradford dye-binding protein assay. A mechanism for dye binding to protein has been proposed, based on measuring Coomassie Brilliant Blue G-250 (CBBG) absorbance spectra during titration of the dye reagent in the absence of protein and its response to different polyamino acids. Brilliant Blue G has been used for determining critical micelle concentration of detergents.
synthetische
Benzaldehyde ?(1 Moore) and N-ethyl-N-benzyl-3-methylaniline?(2 Moore) condensation, And then sulfonating the product of three acids, and lead oxide, peroxide, and then the reaction with the 4-Ethoxybenzenamine, Benzaldehyde ?sulfonic acid groups on the phenyl ring is substituted anilino-ethoxy.
Allgemeine Beschreibung
Brilliant Blue G (BBG) is a dye. It has been proposed as a substitute for internal limiting membrane (ILM) peeling.
Flammability and Explosibility
Not classified
Biologische Aktivität
brilliant blue g is also a selective inhibitor of the p2x purinoceptor channel p2x7 [1].p2x receptors are membrane ion channels activated in response to the binding of extracellular atp. seven p2x subtypes have been identified. p2x receptors have been involved in in diverse patho- and physiological processes, such as the autonomic nervous system, afferent signalling, chronic pain, and in autocrine loops of endothelial and epithelial cells. the p2x7 receptor plays a prominent role in certain neurologic disorders, such as ischemia-reperfusion injury, alzheimer's disease, spinal cord injury and sensory neuropathies [2].in hek293 cells heterologously expressing human p2x7 receptors, brilliant blue g noncompetitively inhibited rat and human p2x7 receptors with ic50 values of 10 and 200 nm, respectively. the ic50 values for inhibition of the other p2x receptors ranged from 2 to >30 μm; brilliant blue g inhibited the rat and human p2x4 receptors with the ic50 values of >10 and 3.2 μm [1]. subretinal injection of bbg caused retinal cell degeneration at lower concentrations. subretinal injection of bbg (0.25 mg/ml) provided satisfactory biocompatibility [3].
Biochem/physiol Actions
P2X7 purinergic receptor antagonist.
Lager
Room temperature

Properties and Applications

bright blue. Dark brown powder, slightly soluble in water, soluble in hot water (bright blue) and ethanol (bright blue). When a blood-red of sulfuric acid, a orange red after diluted. Its water solution and sodium hydroxide for purple. Used for wool and silk dyeing, also can be used for leather dyeing.

Standard	Light Fastness	Soaping		Persperation Fastness	Oxygen bleaching		Fastness to seawater
Standard	Light Fastness	Fading	Stain	Persperation Fastness	Fading	Stain	Fading	Stain
ISO	3	3	4-5	3-4	1	1	4	4
AATCC	3	3-4	3-4	4-5	1	1	Einzelnachweise [1] jiang l h, mackenzie a b, north r a, et al. brilliant blue g selectively blocks atp-gated rat p2x7 receptors[j]. molecular pharmacology, 2000, 58(1): 82-88. [2] sperlágh b, vizi e s, wirkner k, et al. p2x 7 receptors in the nervous system[j]. progress in neurobiology, 2006, 78(6): 327-346. [3] ueno a, hisatomi t, enaida h, et al. biocompatibility of brilliant blue g in a rat model of subretinal injection[j]. retina, 2007, 27(4): 499-504. Acid Blue 90 Upstream-Materialien And Downstream Produkte Upstream-Materialien N-benzyl-N-ethyl m-toluidine 4-Ethoxyanilin N-Benzyl-N-ethyl-m-toluidin Trisulfonic acid Benzaldehyd 4-Ethoxyanilin N-Benzyl-N-ethyl-m-toluidin Benzaldehyd 1of2 Downstream Produkte ACID BLUE 9 ALUMINUM LAKE Dihydrogen(ethyl)[4-[4-[ethyl(3-sulfonatobenzyl)]amino]-2'-sulfonatobenzhydryliden]cyclohexa-2,5-dien-1-yliden](3-sulfonatobenzyl)ammonium, Dinatriumsalz Hydrogen[4-[4-(p-ethoxyanilino)-4'-[ethyl(m-sulfonatobenzyl)amino]-2'-methylbenzhydrylen]-3-methylcyclohexa-2,5-dien-1-yliden](ethyl)(m-sulfonatobenzyl)ammonium, Mononatriumsalz Anbieter Lieferant Produzent Hersteller Vertrieb Händler. Global(410)Suppliers Region Americas 1 Austria 1 Belgium 1 Canada 2 China 280 Europe 4 France 2 Germany 10 India 32 Japan 7 Mexico 1 Poland 1 Spain 1 Switzerland 3 The Netherlands 2 United Kingdom 15 United States 46 USA 1 Clear All Done AFINE CHEMICALS LIMITED Telefon 0571-85134551 E-Mail info@afinechem.com Shanghai Daken Advanced Materials Co.,Ltd Telefon +86-371-66670886 E-Mail info@dakenam.com career henan chemical co Telefon +86-0371-86658258 E-Mail sales@coreychem.com Hubei Jusheng Technology Co.,Ltd. Telefon 18871490254 E-Mail linda@hubeijusheng.com Chongqing Chemdad Co., Ltd Telefon +86-023-61398051<br/>+8613650506873 E-Mail sales@chemdad.com Winchem industrial co limited Telefon +86-0086-574-83851061<br/>+86-13003762012 E-Mail lucyhu@win-chemical.com Shenyang Simchoice Chemical Co.,Ltd Telefon +86-024-23769576<br/>+86-15040101888 E-Mail sales@simchoicechem.com CONIER CHEM AND PHARMA LIMITED Telefon +8618523575427 E-Mail sales@conier.com SIMAGCHEM CORP Telefon +86-13806087780 E-Mail sale@simagchem.com Hebei Runbin Biotechnology Co. LTD Telefon 13180553332 E-Mail 2179877681@qq.com 1of2 6104-58-1, Acid Blue 90 Verwandte Suche: Thiophanat-methyl Methylthenoat Phenylvalerat Folsure Zitronensure Kresoxim-methyl Hyaluronsure ACETIC ACID Bensulfuron methyl ACID BLUE 1 Methyl-4-hydroxybenzoat Methylacrylat Natrium-1-amino-9,10-dioxo-4-phenylaminoanthracen-2-sulfonat Acid chrome blue K Hydrogen[4-[4-(p-ethoxyanilino)-4'-[ethyl(m-sulfonatobenzyl)amino]benzhydrylen]cyclohexa-2,5-dien-1-yliden](ethyl)(m-sulfonatobenzyl)ammonium, Mononatriumsalz Dinatrium-7-hydroxy-8-phenylazonaphthalin-1,3-disulfonat Trinatrium-5-hydroxy-1-(4-sulfophenyl)-4-(4-sulfophenylazo)pyrazol-3-carboxylat Trinatrium-3-hydroxy-4-(4'-sulfonatonaphthylazo)naphthalin-2,7-disulfonat 1of4 Send Inquriy Website-Startseite\| CAS\| Die PC-Version Chemical Book

Hydrogen[4-[4-(p-ethoxyanilino)-4'-[ethyl(m-sulfonatobenzyl)amino]-2'-methylbenzhydrylen]-3-methylcyclohexa-2,5-dien-1-yliden](ethyl)(m-sulfonatobenzyl)ammonium, Mononatriumsalz

Gefahreninformationscode (GHS)

Acid Blue 90 Chemische Eigenschaften,Einsatz,Produktion Methoden

Acid Blue 90 Upstream-Materialien And Downstream Produkte

Hydrogen[4-[4-(p-ethoxyanilino)-4'-[ethyl(m-sulfonatobenzyl)amino]-2'-methylbenzhydrylen]-3-methylcyclohexa-2,5-dien-1-yliden](ethyl)(m-sulfonatobenzyl)ammonium, Mononatriumsalz Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

6104-58-1, Acid Blue 90 Verwandte Suche: