Glycerintridecanoat

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H225：Flüssigkeit und Dampf leicht entzündbar.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

• Sicherheit

  P210：Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

TRICAPRIN Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R11:Leichtentzündlich.
  R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).

• Beschreibung

  1,2,3-Tridecanoyl glycerol is a triacylglycerol that contains decanoic acid at the sn-1, sn-2, and sn-3 positions. It has been found in human breast milk. 1,2,3-Tridecanoyl glycerol has been used as a standard for the quantification of triacylglycerols in fish oils by RP-HPLC. Formulations containing 1,2,3-tridecanoyl glycerol have been used in cosmetic products as thickening and skin-conditioning agents.

• Verwenden

  Tricaprin is used to construct solid lipid nanoparticles (SLNs) as delivery system for bromocriptine (B682600, Mesylate salt). It is also used in cationic SLNs to enhance p53 tumor suppressor gene transfer to lung cancer cells.

• Definition

  ChEBI: A triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by capric (decanoic) acid.

• in vivo

  Trisdecanoin (Intravenous injection (i.v.); 1h, 4h) can promote the metabolism of long chain fatty acids (LCFA) in the heart muscle of Atgl KO mice in lipotriglyceride lipase (Atgl) gene knockout (KO) mice. Effect of reducing lipid accumulation in the heart of AtglKO mice and improving left ventricular function of AtglKO mice^[2].
  Trisdecanoin (1145 mg/kg/day; Oral gavage (p.o.); two weeks) can prevent and inhibit the development of abdominal aortic aneurysms and alleviate the apoptosis and dysfunction of early smooth muscle cells (SMCs) in Male Sprague-Dawley rat models^[3].
  

  Animal Model:	Male Sprague-Dawley rats[3]
  Dosage:	1145 mg/kg/day
  Administration:	Oral gavage (p.o.)
  Result:	There was no significant difference in the incidence of AAA between the control and ricaprylin groups (30.2% vs 24.0%). In contrast, the incidence of AAA in Trisdecanoin was significantly lower than in the control group (30.2% vs. 3.6%). The AAA rupture rates in control group and C8-TG group were 31.3% and 33.3%, respectively. There was no aneurysm rupture in Trisdecanoin group. The mean aortic diameter of Trisdecanoin group was significantly lower than that of control group..

• Einzelnachweise

  [1] KIM K M, PARK T S, SHIM S M. Optimization and validation of HRLC-MS method to identify and quantify triacylglycerol molecular species in human milk[J]. Analytical Methods, 2015, 10: 4362-4370. DOI: 10.1039/c5ay00591d
  [2] áNGELA GARCíA SOLAESA. Characterization of triacylglycerol composition of fish oils by using chromatographic techniques.[J]. Journal of oleo science, 2014, 63 5: 449-460. DOI: 10.5650/jos.ess13202
  [3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.

TRICAPRIN Upstream-Materialien And Downstream Produkte

Glycerintridecanoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(200)Suppliers

621-71-6, TRICAPRIN Verwandte Suche: