Dexrazoxane Struktur

Dexrazoxane

Bezeichnung:Dexrazoxane

CAS-Nr24584-09-6

Englisch Name:Dexrazoxane

CBNumberCB2251448

SummenformelC11H16N4O4

Molgewicht268.27

MOL-Datei24584-09-6.mol

Dexrazoxane physikalisch-chemischer Eigenschaften

Schmelzpunkt	194-196°C
alpha	D +11.35° (c = 5 in DMF)
Siedepunkt	531.5±50.0 °C(Predicted)
Dichte	1.333±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: >20mg/mL
Aggregatzustand	powder
pka	2.1(at 25℃)
Farbe	white to off-white
Merck	14,8123
InChIKey	BMKDZUISNHGIBY-ZETCQYMHSA-N
CAS Datenbank	24584-09-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
RTECS-Nr.	TL6390000
HS Code	2933.59.9500
Giftige Stoffe Daten	24584-09-6(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Dexrazoxane Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Dexrazoxane is the dextro-isomer of razoxane approved as a protectant against the cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the anticancer effect of doxorubicin. Its mode of action suggests a chelation of free radicals. In mice, dexrazoxane also offers protection against cardiac side effects of epirubicin, but not mitoxantrone.
Originator
Imperial Cancer Research Fund (United Kingdom)
Verwenden
Cardioprotectant.
Verwenden
Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.
Verwenden
Dexrazoxane has been used in chromatin remodelling experiments.
Definition
ChEBI: (+)-dexrazoxane is a razoxane. It has a role as a chelator, an antineoplastic agent, a cardiovascular drug and an immunosuppressive agent.
Trademarks
Zinecard (Pharmacia & Upjohn);Cardioxane.
Allgemeine Beschreibung
Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs.
Biologische Aktivität
Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.
Biochem/physiol Actions
Dexrazoxane is a cardioprotective compound against anthracyclines. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.
Clinical Use
Cardioxane? Prevention of cardiotoxicity in patients receiving doxorubicin or epirubicin for breast cancer Savene? : Treatment of extravasation caused by anthracyclines
Veterinary Drugs and Treatments
Dexrazoxane may be useful to attenuate the cardiotoxic effects of doxorubicin in patients who are showing signs of anthracycline cardiotoxicity, have cardiac disease, or are at maximum cumulative dosages of doxorubicin. It is also used to treat extravasation injuries associated with doxorubicin.
While dexrazoxane has been shown to be cardioprotective when given at dosages of 10 times the doxorubicin dose, there is evidence that it may also partially protect the cancer cells being treated.
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Antiepileptics: may reduce absorption of fosphenytoin and phenytoin.
Ciclosporin: increased risk of immunosuppression with risk of lymphoproliferative disease.
Tacrolimus: increased risk of immunosuppression with risk of lymphoproliferative disease.
Vaccines: risk of generalised infections with live vaccines - avoid.
Stoffwechsel
Dexrazoxane is hydrolysed by the enzyme dihydropyrimidine amidohydrolase in the liver and kidney to active metabolites that are capable of binding to metal ions.
It is excreted unchanged via the kidney

Dexrazoxane Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

24584-09-6, Dexrazoxane Verwandte Suche:

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