L-(-)-Ephedrine Struktur

L-Norephedrin

Bezeichnung:L-Norephedrin

CAS-Nr492-41-1

Englisch Name:L-(-)-Ephedrine

CBNumberCB2159410

SummenformelC9H13NO

Molgewicht151.21

MOL-Datei492-41-1.mol

Synonyma

[R-(R*,S*)]-α-(1-Aminoethyl)benzylalkohol

L-Norephedrin

L-Norephedrin physikalisch-chemischer Eigenschaften

Schmelzpunkt	51-53 °C(lit.)
alpha	-41 º (c=7, 1M HCl)
Siedepunkt	273.23°C (rough estimate)
Dichte	1.0406 (rough estimate)
Brechungsindex	1.5380 (estimate)
Flammpunkt	>230 °F
storage temp.	2-8°C
Aggregatzustand	A solid
pka	9.958(at 10℃)
Stabilität	Stable. Incompatible with strong oxidizing agents. May discolour on exposure to light.
CAS Datenbank	492-41-1(CAS DataBase Reference)
NIST chemische Informationen	Phenylpropanolamine(492-41-1)
EPA chemische Informationen	Benzenemethanol, .alpha.-[(1S)-1-aminoethyl]-, (.alpha.R)- (492-41-1)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26
WGK Germany	3
RTECS-Nr.	RC2275000
F	3-8-10
Hazard Note	Harmful
Toxizität	LD50 orl-rat: 1538 mg/kg BCFAAI 109,132,70

Gefahreninformationscode (GHS)

L-(-)-Ephedrine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
This alkaloid was first isolated by Kanao from the Chinese drug 'Ma-Huang' (Ephedra sinica Stapf.) and later by Wolfes from E. helvetica C. A. Meyer and E. distachya Linn. It forms a crystalline mass and has [α] ²⁰ _D - 14.56° (EtOH). Several crystalline salts and derivatives are known: the hydrochloride has m.p. 171-2°C; [α] ²⁰ _D- 33.27° (H20); the sulphate dihydrate, m.p. 285-6°C (dry, dec.); [α] ²⁸ _D- 31.99° (H20); the aurichloride, m.p. 188°C; platinichloride, m.p. 221°C (dec.); (-)-hydrogen tartrate, m.p. about 160° after sintering at 130°C; oxalate, m.p. 245°C (dec.) and the p-nitrobenzoyl derivative, m.p. 175-6°C; [α] ²⁸ _D- 49.58° (CHCI3).
The (+)-form has m.p. 52°C; [α] ²⁷ _D + 14.76° (EtOH), yielding a hydro_x0002_chloride, m.p. 171-2°C; [α] ²⁷ _D + 33.4° (EtOH); sulphate dihydrate, m.p. 285- 6°C (dry, dec.); [α] ²⁷ _D+ 31.51 0 C (H20); aurichloride, m.p. 188°C (dec.) and platinichloride, m.p. 221.5°C (dec.). The (±)-form crystallizes as colourless plates from Et20, m.p. 104-5°C and also furnishes a series of crystalline salts and derivatives.
Chemische Eigenschaften
white powder
Verwenden
A metabolite of Phenmetrazine.
Definition
ChEBI: (-)-norephedrine is an amphetamine that is propylbenzene substituted by a hydroxy group at position 1 and by an amino group at position 2 (the 1R,2S-stereoisomer). It is a plant alkaloid. It has a role as a plant metabolite. It is a member of amphetamines and a phenethylamine alkaloid.
Sicherheitsprofil
A human poison by ingestion. Poison experimentally by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by an unspecified route. Human systemic effects by ingestion: sleep, increased pulse rate without blood pressure decrease, and chronic pulmonary edema or congestion, convulsions, headache, and blood pressure elevation. Used in production of drugs of abuse. When heated to decomposition it emits toxic fumes of NOx.
Einzelnachweise
Kanao., Ber., 63,95 (1930) Wolfes., Arch. Pharrn., 268,87 (1930) Hey., J. Chern. Soc., 1232 (1930) Akabori, Momotani., J. Chern. Soc., Japan, 64, 608 (1943) Hoover, Hass., J. Org. Chern., 12,506 (1947)

L-(-)-Ephedrine Upstream-Materialien And Downstream Produkte

492-41-1, L-(-)-Ephedrine Verwandte Suche:

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