DEXBROMPHENIRAMINE MALEATE Struktur

DEXBROMPHENIRAMINE MALEATE

Bezeichnung:DEXBROMPHENIRAMINE MALEATE

CAS-Nr2391-03-9

Englisch Name:DEXBROMPHENIRAMINE MALEATE

CBNumberCB1675360

SummenformelC20H23BrN2O4

Molgewicht435.31

MOL-Datei2391-03-9.mol

DEXBROMPHENIRAMINE MALEATE physikalisch-chemischer Eigenschaften

Schmelzpunkt	132-134℃
storage temp.	-20°C Freezer
Löslichkeit	Methanol (Slightly), Water (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	22-36/37/39-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	US4026200
HS Code	2933399090
Toxizität	guinea pig,LD50,oral,259mg/kg (259mg/kg),SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYEBEHAVIORAL: TREMORBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Chemotherapia. Vol. 3, Pg. 120, 1961.

Gefahreninformationscode (GHS)

DEXBROMPHENIRAMINE MALEATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Originator
Disomer,White,US,1959
Verwenden
The S-enantimer of Brompheniramine maleate (B686355) as antihistaminic.
Definition
ChEBI: The maleic acid salt of the (pharmacologically active) (S)-(+)-enantiomer of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and co junctivitis.
Manufacturing Process
The following is taken from US Patent 3,061,517. Sixteen grams of racemic 3- (2-pyridyl)-3-p-bromophenyl-N,N,-dimethylpropylamine and 9.7 grams of dphenylsuccinic acid are dissolved in 150 ml of absolute alcohol and kept at room temperature until crystallization is effected. The crystals are filtered,washed with absolute ethyl alcohol, and recrystallized from the same solvent using 5 ml there of per gram of solid. Three subsequent crystallizations from 80% alcohol give d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamined-phenylsuccinate; MP 152-154°C; [α]D25 91 (concentration, 1% in dimethylformamide).
The free base, d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamine, is obtained from this salt with diethyl ether and aqueous potassium carbonate; [α]D25 +42.7 (concentration, 1% in dimethylformamide). The free base is then reacted with maleic acid.
Trademarks
Disomer (Schering).
Therapeutic Function
Antihistaminic
Allgemeine Beschreibung
Like the chlorinederivative, the antihistaminic activity of brompheniramineexists predominantly in the dextro isomer, dexbrompheniraminemaleate (D-isomer), and is of comparable potency.
Biologische Aktivität
Antihistamine; H1 histamine receptor antagonist.

DEXBROMPHENIRAMINE MALEATE Upstream-Materialien And Downstream Produkte

DEXBROMPHENIRAMINE MALEATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2391-03-9, DEXBROMPHENIRAMINE MALEATE Verwandte Suche:

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