Dexbrompheniramin

DEXBROMPHENIRAMINE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Disomer,White,US,1959

• Verwenden

  Antihistaminic.

• Definition

  ChEBI: The (pharmacologically active) (S)-(+)-enantiomer of brompheniramine. A histamine H1 receptor antagonist, it is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis nd conjunctivitis.

• Manufacturing Process

  The following is taken from US Patent 3,061,517. Sixteen grams of racemic 3- (2-pyridyl)-3-p-bromophenyl-N,N,-dimethylpropylamine and 9.7 grams of dphenylsuccinic acid are dissolved in 150 ml of absolute alcohol and kept at room temperature until crystallization is effected. The crystals are filtered,washed with absolute ethyl alcohol, and recrystallized from the same solvent using 5 ml there of per gram of solid. Three subsequent crystallizations from 80% alcohol give d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamined-phenylsuccinate; MP 152-154°C; [α]D25 91 (concentration, 1% in dimethylformamide).
  The free base, d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamine, is obtained from this salt with diethyl ether and aqueous potassium carbonate; [α]D25 +42.7 (concentration, 1% in dimethylformamide). The free base is then reacted with maleic acid.

• Trademarks

  Disomer (Schering).

• Therapeutic Function

  Antihistaminic

DEXBROMPHENIRAMINE Upstream-Materialien And Downstream Produkte

Dexbrompheniramin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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