3,3',5,5'-TETRAMETHYLBENZIDINE DIHYDROCHLORIDE HYDRATE

Bezeichnung:3,3',5,5'-TETRAMETHYLBENZIDINE DIHYDROCHLORIDE HYDRATE

CAS-Nr207738-08-7

Englisch Name:3,3',5,5'-TETRAMETHYLBENZIDINE DIHYDROCHLORIDE HYDRATE

CBNumberCB1500794

SummenformelC16H23ClN2O

Molgewicht294.82

MOL-Datei207738-08-7.mol

3,3',5,5'-TETRAMETHYLBENZIDINE DIHYDROCHLORIDE HYDRATE physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300°C
storage temp.	2-8°C
Löslichkeit	Soluble in DMSO (~1.7 mg/ml), and 1:300 DMSO:PBS (pH 7.2) (0.03 mg/ml).
Aggregatzustand	Powder
Sensitive	Moisture & Light Sensitive
InChIKey	NYNRGZULARUZCC-UHFFFAOYSA-N
CAS Datenbank	207738-08-7

Sicherheit

R-Sätze:	22
S-Sätze:	22-24/25-25-24
WGK Germany	3
TSCA	Yes
HS Code	29215900

Gefahreninformationscode (GHS)

3,3',5,5'-TETRAMETHYLBENZIDINE DIHYDROCHLORIDE HYDRATE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
TMB is an aromatic amine that undergoes oxidation by the higher oxidation states of heme peroxidases (compounds I and II) thereby serving as a reducing co-substrate. One electron oxidation of TMB results in a radical cation that forms a charge-transfer complex with the unoxidized compound. This charge transfer complex absorbs at 652 nm (ε = 39,000). The completely oxidized form (diimine) absorbs at 450 nm (ε = 59,000) and is formed by two sequential one-electron oxidations of TMB. Thus the stoichiometry of oxidation is 0.5 mole charge transfer complex (λ_max = 652 nm) or 1 mole of diimine (λ_max = 450 nm) formed (or TMB oxidized) per mole of hydroperoxide reduced by the peroxidase.
Chemische Eigenschaften
Off-white fluffy powder
Verwenden
3,3′,5,5′-Tetramethylbenzidine dihydrochloride hydrate has also been used as a horseradish peroxidase substrate in enzyme linked immunosorbent assay and reverse dot blot (RDB).
Verwenden
Convenient water-soluble form of TMB for determination of peroxidase.
Verwenden
3,3',5,5'-Tetramethylbenzidine dihydrochloride hydrate is a chromophore substrate in ELISA assays. It is a noncarcinogenic substitute for benzidine.
Allgemeine Beschreibung
3,3′,5,5′-Tetramethylbenzidine dihydrochloride hydrate (TMB-d) is a sensitive chromogen substrate for peroxidase. It is non- carcinogenic, hence, it can be used as a safe substitute for benzidine. TMB-d is useful in quantifying hemoglobin and in staining myeloperoxidase-containing granules in granulocytes.

3,3',5,5'-TETRAMETHYLBENZIDINE DIHYDROCHLORIDE HYDRATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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