2,4,6-Trimethylanilin

Bezeichnung:2,4,6-Trimethylanilin

CAS-Nr88-05-1

Englisch Name:2,4,6-Trimethylaniline

CBNumberCB5410640

SummenformelC9H13N

Molgewicht135.21

MOL-Datei88-05-1.mol

Synonyma

2,4,6-Trimethylanilin

2,4,6-Trimethylanilin physikalisch-chemischer Eigenschaften

Schmelzpunkt	-5 °C
Siedepunkt	108-110 °C11 mm Hg(lit.)
Dichte	0.963 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.551(lit.)
Flammpunkt	205 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
Aggregatzustand	liquid (clear)
pka	pK1:4.38(+1) (25°C)
Farbe	clear brown
Wasserlöslichkeit	IMMISCIBLE
BRN	636559
InChIKey	KWVPRPSXBZNOHS-UHFFFAOYSA-N
CAS Datenbank	88-05-1(CAS DataBase Reference)
IARC	3 (Vol. 27, Sup 7) 1987
NIST chemische Informationen	Benzenamine, 2,4,6-trimethyl-(88-05-1)
EPA chemische Informationen	2,4,6-Trimethylaniline (88-05-1)

Sicherheit

Kennzeichnung gefährlicher	T+,T
R-Sätze:	21/22-26-36/38-33-23/24/25
S-Sätze:	26-28-36/37-45-28A
RIDADR	UN 2810 6.1/PG 2
WGK Germany	3
RTECS-Nr.	BZ0700000
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29214980
Giftige Stoffe Daten	88-05-1(Hazardous Substances Data)

Gefahreninformationscode (GHS)

2,4,6-Trimethylaniline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R21/22:Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken.
R26:Sehr giftig beim Einatmen.
R36/38:Reizt die Augen und die Haut.
R33:Gefahr kumulativer Wirkungen.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
clear yellow to brown liquid. Insoluble in water, soluble in organic solvents such as ethanol and ether.
Verwenden
2,4,6-Trimethylaniline is useful for the preparation of Grubbs' catalyst. It is used as a precursor to dyes. It undergoes condensation reaction with glyoxal to prepare glyoxal-bis(mesitylimine). It is also involved in the preparation of 1,3-diketimines ligands by condensation with 1,3-diketones. Further, it is used for the production of Acid Blue 129 dye, which is useful in histochemistry studies. In addition to this, it serves as a building block to various bulky ligands.
synthetische
2,4,6-Trimethylaniline is prepared by selective mononitration of mesitylene, avoiding oxidation of the methyl groups.
Mix sulfuric acid and nitric acid into mixed acid, nitrify with mesitylene at atmospheric pressure below 10°C for 4 hours, stand for stratification, and let off the waste acid. The obtained 2,4,6-trimethylnitrobenzene, iron powder, hydrochloric acid and water were prepared in a ratio of 1:3.74:0.9:2.22 (mol ratio) for reduction reaction at 100-105°C for 8h. Crude 2,4,6-Trimethylaniline was then distilled off from the reduced material and purified by distillation.
Definition
ChEBI: 2,4,6-Trimethylaniline is a substituted aniline.
Allgemeine Beschreibung
2,4,6-Trimethylaniline is a clear liquid. easily turns light brown when exposed to air and light. It is an intermediate for dyes, organic pigments and pesticides.
Reaktivität anzeigen
2,4,6-Trimethylaniline neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard
2,4,6-Trimethylaniline is moderately toxic orally. It is also considered highly toxic by unspecified routes. It is a skin and eye irritant. Suspect occupational carcinogen. (Non-Specific -- Aromatic Amines) The danger of acute poisoning is represented by methemoglobinemia leading to adverse effects on the red cells. A number of the amines may act as skin sensitizers.
Brandgefahr
When heated to decomposition, 2,4,6-Trimethylaniline emits toxic fumes of nitrogen oxides. Avoid decomposing heat.
Sicherheitsprofil
Poison by inhalation. Moderately toxic by ingestion. A skin and severe eye irritant. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
mögliche Exposition
Used on small scale in organic synthesis.
Versand/Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

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