BIS(METHYLTHIO)GLIOTOXIN Struktur

BIS(METHYLTHIO)GLIOTOXIN

Bezeichnung:BIS(METHYLTHIO)GLIOTOXIN

CAS-Nr74149-38-5

Englisch Name:BIS(METHYLTHIO)GLIOTOXIN

CBNumberCB1288191

SummenformelC15H20N2O4S2

Molgewicht356.46

MOL-Datei74149-38-5.mol

BIS(METHYLTHIO)GLIOTOXIN physikalisch-chemischer Eigenschaften

Siedepunkt	669.6±55.0 °C(Predicted)
Dichte	1.49±0.1 g/cm3(Predicted)
storage temp.	−20°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	White solid.
pka	12.69±0.60(Predicted)
Farbe	Off-White to Yellow

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22
S-Sätze:	36
RIDADR	1544
HazardClass	6.1(b)
PackingGroup	III

Gefahreninformationscode (GHS)

BIS(METHYLTHIO)GLIOTOXIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC₅₀s = 8.4 and 84.2 μM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC₅₀s = >400 μM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC₅₀ = 23.56 μM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD₅₀ = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.
Verwenden
Bis(methylthio)gliotoxin (FR-49175) is an antiphagocytic metabolite.
Enzyminhibitor
This naturally occurring indole derivative (FW = 356.47 g/mol; CAS 74149- 38-5), also known as bis(methylthio)gliotoxin and dimethylgliotoxin, is a platelet-acivating factor (PAF) antagonist that inhibits PAF-induced platelet aggregation. The parent compound, gliotoxin is a dual inhibitor of famesyltransferase and geranylgeranyl-transferase. Bisdethiobis(methylthio)gliotoxin is a minor metabolite of Gliocladium deliquescens, Radiocarbon tracer experiments showed it is formed, apparently irreversibly, from gliotoxin. It has also been synthesized from gliotoxin by reduction and methylation. Bisdethio-bis(methylthio)gliotoxin also binds Cu+ and Ag+ ions.

BIS(METHYLTHIO)GLIOTOXIN Upstream-Materialien And Downstream Produkte

BIS(METHYLTHIO)GLIOTOXIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

74149-38-5, BIS(METHYLTHIO)GLIOTOXIN Verwandte Suche:

Send Inquriy