Poly(ethylene glycol) distearate

Gefahreninformationscode (GHS)

• Alarmwort

  Warnung

Poly(ethylene glycol) distearate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  A soft, off-white solid. PH of 10% dispersion 7.26, saponification number variable. Soluble in chlorinated solvents, light esters, and acetone; slightly soluble in alcohols, insoluble in glycols, hydrocarbons, and vegetable oils. Combustible.

• Verwenden

  Pegosperse(R) 300 DS is used as an emulsifier for personal care and water treatment and as a processing aid in textile industry.

• Verwenden

  POLY(ETHYLENE GLYCOL) (N) DISTEARATE is used as an emulsifier for personal care and water treatment and as a processing aid in textile industry.

• Definition

  Distearate ester of polyglycol.

• Vorbereitung Methode

  Polyethylene glycol distearate is prepared by the direct reaction of fatty acids, particularly stearic acid, with ethylene oxide.

• Pharmazeutische Anwendungen

  Polyethylene glycol distearate is generally used as emulsifiers in oil-inwater- type creams and lotions. Its hydrophilicity or lipophilicity depends on the number of ethylene oxide units present: the larger the number, the greater the hydrophilic properties. Polyoxyl 40 stearate has been used as an emulsifying agent in intravenous infusions.
  Polyoxyethylene stearates are particularly useful as emulsifying agents when astringent salts or other strong electrolytes are present. It can also be blended with other surfactants to obtain any hydrophilic–lipophilic balance for lotions or ointment formulations.

• Sicherheitsprofil

  Poison by intravenous route. When heated to decomposition it emits acrid smoke and irritating fumes. See also POLYETHYLENE GLYCOL.

• Sicherheit(Safety)

  Although Polyethylene glycol distearate is primarily used as emulsifying agents in topical pharmaceutical formulations, certain materials, particularly polyoxyl 40 stearate, have also been used in intravenous injections and oral preparations.
  Polyethylene glycol distearate has been tested extensively for toxicity in animals(8–13) and are widely used in pharmaceutical formulations and cosmetics. It is generally regarded as essentially nontoxic and nonirritant materials.
  Polyoxyl 8 stearate
  (hamster, oral): 27 g/kg
  (rat, oral): 64 g/kg
  Polyoxyl 20 stearate
  (mouse, IP): 0.2 g/kg
  (mouse, IV): 0.87 g/kg

• Lager

  Polyoxyethylene stearates are generally stable in the presence of electrolytes and weak acids or bases. Strong acids and bases can cause gradual hydrolysis and saponification.
  The bulk material should be stored in a well-closed container, in a dry place, at room temperature.

• Inkompatibilitäten

  Polyethylene glycol distearate is unstable in hot alkaline solutions owing to hydrolysis, and will also saponify with strong acids or bases. Discoloration or precipitation can occur with salicylates, phenolic substances, iodine salts, and salts of bismuth, silver, and tannins.Complex formation with preservatives may also occur.The antimicrobial activity of some materials such as bacitracin, chloramphenicol, phenoxymethylpenicillin, sodium penicillin, and tetracycline may be reduced in the presence of polyoxyethylene stearate concentrations greater than 5% w/w.

• Regulatory Status

  Included in the FDA Inactive Ingredients Database (dental solutions; IV injections; ophthalmic preparations; oral capsules and tablets; otic suspensions; topical creams, emulsions, lotions, ointments, and solutions; and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Poly(ethylene glycol) distearate Upstream-Materialien And Downstream Produkte

Poly(ethylene glycol) distearate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(94)Suppliers

9005-08-7, Poly(ethylene glycol) distearate Verwandte Suche: