Benzalkonium chloride

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H314：Verursacht schwere Verätzungen der Haut und schwere Augenschäden.

  H400：Sehr giftig für Wasserorganismen.

• Sicherheit

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P301+P330+P331：BEI VERSCHLUCKEN: Mund ausspülen. KEIN Erbrechen herbeiführen.

  P303+P361+P353：BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

  P304+P340：BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P310：Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen.

  P321：Besondere Behandlung

  P330：Mund ausspülen.

  P363：Kontaminierte Kleidung vor erneutem Tragen waschen.

  P391：Verschüttete Mengen aufnehmen.

  P405：Unter Verschluss aufbewahren.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Benzalkonium chloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  Benzethonium chloride appears as odorless white crystals or powder with a very bitter taste. A 1% solution in water is slightly alkaline to litmus.

• Verwenden

  Benzalkonium chloride is a highly concentrated quaternary ammonium antimicrobial used in a broad number of applications.
  Benzalkonium chloride (BAK) is a common preservative used in ophthalmic medications and is the active ingredient in some skin disinfectants and hand sanitizers. BAK is known to be effective in killing bacteria and enveloped viruses. However, its activity against non-enveloped viruses is unknown.
  Benzalkonium chloride (as Roccal or Zephiran) was found to inactivate influenza, measles, canine distemper, rabies, fowl laryngotracheitis, vaccinia, Semliki Forest, feline pneumonitis, meningopneumonitis, and herpes simplex viruses after 10 min of exposure at 30 C or at room temperature. Poliovirus and encephalomyocarditis virus were not inactivated under the same conditions.
  Benzalkonium chloride is also used as a topical anti-infective in medicine as well as a germicide for cleansing food and dairy utensils, and as a controlling agent for swimming pool algae. It is also an additive in deodorants and hairdressing preparations.

• Indications

  Benzalkonium chloride is a quaternary ammonium detergent that treats grampositive and gram-negative organisms. Strains of Mycobacterium tuberculosis and Pseudomonas aeruginosa are often resistant. It is not effective against spore-forming organisms. It is nonirritating to mucous membranes and may be used near the eyes. Drawbacks include lack of sustained activity and ease of contamination of this antimicrobial. It is inactivated by anionic compounds such as soap. A 0.1% solution takes 7 minutes to decrease the bacterial count by 50%. All traces of soap must be removed with 70% alcohol before use.

• Clinical Use

  Benzalkonium chloride, a quaternary ammonium compound, is found as a preservative in contact lens cleaning solutions, soaps, and skin care products and is used as a disinfectant and impregnated on medical devices to prevent bacterial colonization. Localized Cou has been described to cutaneous contact with a toilet cleaner.Parenteral and mucosal exposure has been documented to result in a generalized urticaria, respiratory compromise, and anaphylaxis. It was used as a preservative in bronchodilator nebulizer solutions; however, it was proven to cause bronchoconstriction in some asthmatic patients and a call for its withdrawal from these products occurred in 2001.Whether these effects are related to an IgE-mediated mechanism has not been established.
  Bernstein et al. describe a case of combined occupational asthma and localized and generalized Cou to contact with benzalkonium chloride in a toilet cleaner. They could not show benzalkonium chloride-specific IgE antibodies in the serum of this patient.
  Benzalkonium chloride in nasal drops,eye drops,nebulizer solution,and a benzalkonium-coated central venous catheter have been documented to cause immediate generalized reactions and anaphylaxis.

• Enzyminhibitor

  This cationic surface-active disinfectant and preservative (FWlauryl-homologue = 340.00 g/mol; CAS 8001-54-5; Soluble in Ethanol and Acetone), also named alkyldimethylbenzyl-ammonium chloride, refers to several cationic detergents that are widely used in various pharmaceutical preparations, including eye, ear, and nasal drops as well as leave-on antiseptics. (See also specific agent) Benzalkonium chloride has also been used in the isolation and purification of proteins and as an antimicrobial agent. Commercial sources typically contain a mixture of alkyl homologues, predominantly with a dodecyl (lauryl) side-chain. Standard concentrates are manufactured as 50% and 80% w/w solutions, and sold under trade names such as BC50, BC80, BAC50, and BAC80. Target (s) : acetylcholinesterase, esterase activity; butyrylcholinesterase, esterase activity (but activates the aryl acylamidase activity); trypsin; chymotrypsin; histamine release; G proteins ; serralysin; chitosanase.

Benzalkonium chloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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