4-(Acetamido)benzoesure, Verbindung mit 2-(Dimethylamino)ethanol (1:1)

4-(acetamido)benzoic acid, compound with 2-(dimethylamino)ethanol (1:1) Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Deaner ,Riker,US,1958

• Verwenden

  Pabenol is used in the treatment of mild cognitive deficit.

• Manufacturing Process

  About 40 grams (0.223 mol) of p-acetylaminobenzoic acid was dissolved in 600 ml of absolute methanol, and the solution was heated to reflux temperature. Heating was discontinued, and, with mechanical stirring, 19.9 grams (0.223 mol) of 2-dimethylaminoethanol was added through a dropping funnel as fast as the exothermic nature of the reaction permitted. The reaction mixture was allowed to cool to room temperature (2.5-3 hours) under mechanical agitation, and the solution was suction-filtered through Celite filter aid. The filtrate was poured into 500 ml of anhydrous ethyl ether, seeded with a few crystals of 2-dimethylaminoethanol p-acetylaminobenzoate. The seeding crystals were obtained by introducing 3 to 6 drops of the filtered reaction mixture into a test tube containing 10 ml of anhydrous diethyl ether. The contents of the test tube were thoroughly shaken and allowed to stand at room temperature. The salt crystallized out within not more than 10-15 minutes.
  The crude product (48.4 grams, 80.9% yield) was recrystallized from an absolute ethanol-ethyl acetate solvent system by suspending the salt in boiling anhydrous ethyl acetate and just enough absolute ethanol was gradually added to effect solution after which the solution was concentrated to about two-thirds of the original volume on the steam bath, charcoal treated, and suction-filtered through Celite filter aid. The white crystals of 2- dimethylaminoethanol p-acetylaminobenzoate obtained, dried at room temperature at a pressure of 0.08 mm Hg for 15 hours, melted at 159.0°- 161.5°C.

• Therapeutic Function

  Psychostimulant

4-(acetamido)benzoic acid, compound with 2-(dimethylamino)ethanol (1:1) Upstream-Materialien And Downstream Produkte

4-(Acetamido)benzoesure, Verbindung mit 2-(Dimethylamino)ethanol (1:1) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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