Iotalaminsure

Bezeichnung:Iotalaminsure

CAS-Nr2276-90-6

Englisch Name:Iotalamic acid

CBNumberCB0501411

SummenformelC11H9I3N2O4

Molgewicht613.91

MOL-Datei2276-90-6.mol

Synonyma

Iotalaminsure

Iotalaminsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300 °C (decomp)
Siedepunkt	520.2±50.0 °C(Predicted)
Dichte	2.4079 (estimate)
storage temp.	Refrigerator
Löslichkeit	DMSO (Slightly, Heated), Methanol (Slightly)
Aggregatzustand	Solid
pka	0.78±0.10(Predicted)
Farbe	Off-White to Pale Yellow
CAS Datenbank	2276-90-6(CAS DataBase Reference)

Sicherheit

HS Code	2924296000
Toxizität	man,TDLo,unreported,2143uL/kg (2.143mL/kg),SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYELUNGS, THORAX, OR RESPIRATION: DYSPNEA,AJR, American Journal of Roentgenology. Vol. 162, Pg. 997, 1994.

Gefahreninformationscode (GHS)

Iotalamic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Off-white Solid
Originator
Conray,Mallinckrodt Inc.,US,1962
Verwenden
Iothalamic Acid is used as a contrast medium in diagnostic radiology. Iothalamic Acid displayed the same level of nephrotoxicity against rat and human renal epithelial cells as conventional ionic contrast medioum.
Definition
ChEBI: Iotalamic acid is an organic molecular entity.
Manufacturing Process
Crude 5-amino-2,4,6-triiodo-N-methylisophthalamic acid (21.0 g) was dissolved in warm dimethylacetamide (40 ml) and acetic anhydride (30 ml) and concentrated sulfuric acid (2 drops) were added. This solution was heated on the steam bath for 2 hours, then heated at 110°C for 5 minutes, then cooled. Water and ammonium hydroxide were added to destroy the excess acetic anhydride, after which the mixture was evaporated to a volume of 50 ml. The cooled solution was acidified with concentrated hydrochloric acid and a tan solid was collected. The crude product was dissolved in 100 ml of water containing a slight excess of sodium hydroxide. The pH was adjusted to 4.5 with acetic acid, and the solution was treated with charcoal. The colorless solution was acidified with concentrated hydrochloric acid and cooled, and the precipitate was filtered off and dried under reduced pressure. The resulting 5- acetamido-2,4,6-triiodo-N-methylisophthalamic acid decomposes about 285°C and does not melt below 300°C.
5-acetamido-2,4,6-triiodo-N-methylisophthalamic acid was slurried in water and dissolved by the addition of an equivalent quantity of N-methylglucamine. The solution was evaporated to dryness to yield the meglumate salt of 5- acetamido-2,4,6-triiodo-N-methylisophthalamic acid.
Trademarks
Conray(Mallinckrodt).
Therapeutic Function
Diagnostic aid (radiopaque medium)

Iotalamic acid Upstream-Materialien And Downstream Produkte

Iotalaminsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2276-90-6, Iotalamic acid Verwandte Suche:

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