Paricalcitol

Bezeichnung:Paricalcitol

CAS-Nr131918-61-1

Englisch Name:Paricalcitol

CBNumberCB0500520

SummenformelC27H44O3

Molgewicht416.65

MOL-Datei131918-61-1.mol

Paricalcitol physikalisch-chemischer Eigenschaften

Siedepunkt	564.8±50.0 °C(Predicted)
Dichte	1.121±0.06 g/cm3(Predicted)
Flammpunkt	14℃
storage temp.	Store at -20°C,unstable in solution, ready to use.
Löslichkeit	DMSO : 100 mg/mL (240.02 mM; Need ultrasonic)Ethanol : 12.5 mg/mL (30.00 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
pka	14.34±0.40(Predicted)
Aggregatzustand	Solid
Farbe	White to off-white
InChIKey	BPKAHTKRCLCHEA-UBFJEZKGSA-N
SMILES	C[C@]12CCC/C(=C\C=C3C[C@@H](O)C[C@H](O)C3)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(O)(C)C \|&1:1,10,13,16,20,22,26,r\|
CAS Datenbank	131918-61-1(CAS DataBase Reference)

Sicherheit

RIDADR	UN1170 - class 3 - PG 2 - Ethanol, solution
HS Code	2936299055
Giftige Stoffe Daten	131918-61-1(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Paricalcitol Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Paricalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo.
Beschreibung
Paricalcitol is a synthetic 1,25-dihydroxy vitamin D₂ analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.
Chemische Eigenschaften
White Solid
Originator
Abbott (US)
Verwenden
Antihyperparathyriod
Verwenden
1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.
Verwenden
Synthetic analog of vitamin D. Antihyperparathyroid.
Definition
ChEBI: Paricalcitol is a seco-cholestane and a hydroxy seco-steroid. It has a role as an antiparathyroid drug. It is functionally related to a vitamin D2.
Trademarks
Zemplar (Abbott).
Clinical Use
Vitamin D analogue:
Treatment and prevention of secondary hyperparathyroidism associated with chronic renal failure
Stoffwechsel
Extensively metabolised via hepatic and non-hepatic pathways to form two relatively inactive metabolites. After oral administration of 3 H-paricalcitol, only about 2% of the dose was eliminated unchanged in the faeces, and no parent drug found in the urine.
Approximately 70% of the radioactivity was eliminated in the faeces and 18% was recovered in the urine. Most of the systemic exposure was from the parent drug.

Paricalcitol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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