9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H330：Lebensgefahr bei Einatmen.

  H372：Schädigt bei Hautkontakt und Verschlucken die Organe bei längerer oder wiederholter Exposition.

• Sicherheit

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P314：Bei Unwohlsein ärztlichen Rat einholen / ärztliche Hilfe hinzuziehen.

Vitamin D2 Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R22:Gesundheitsschädlich beim Verschlucken.
  R48/25:Giftig: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Verschlucken.
  R26:Sehr giftig beim Einatmen.
  R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.
  R40:Verdacht auf krebserzeugende Wirkung.
  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

• S-Sätze Betriebsanweisung:

  S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S22:Staub nicht einatmen.

• Beschreibung

  Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer and immunity. Vitamin D may be obtained from many dietary sources, including eggs and fish, and is synthesized in the skin by the conversion of 7-dehydrocholesterol to vitamin D₃ by ultraviolet light. Vitamin D₂ is produced in fungi, including yeast, and invertebrates from ergosterol in response to ultraviolet radiation. In vertebrates as well as host organisms, vitamin D₂ is metabolized first to 25-hydroxyvitamin D₂ and subsequently to the active 1,25-dihydroxyvitamin D₂. Differences in the metabolism and action of vitamin D₂ vs. vitamin D₃ in mammals is a current topic of research interest.

• Chemische Eigenschaften

  Ergocalciferol is an odorless white crystalline solid

• Verwenden

  The synthetic form of vitamin D. Prepared from ergosterol by UV irradiation in a suitable solvent. Commercial solutions are usually made with propylene glycol or sesame oil. Antirachitic

• Verwenden

  Vitamin d2 is fat-soluble, and is stable unless oxidized. It is necessary for growth and maintenance of teeth and bones and the normal utilization of calcium and phosphorus; it is used medicinally in the treatment of rickets and as a dietary supplement. Its sources include fish liver and vitamin d-fortified milk.

• Verwenden

  Rodenticide.

• Verwenden

  Vitamin D2 is formed by photochemical cleavage of ergosterin, which is a side-product of many fermentation processes. Microorganisms usually contain up to 3 percent of ergosterin.

• Verwenden

  antirachitic vitamin; LD50 (rat) 56 mg/kg po

• Definition

  ChEBI: A vitamin D supplement and has been isolated from alfalfa.

• Trademarks

  Deltalin (Lilly); Drisdol(Sanofi Aventis).

• Allgemeine Beschreibung

  Odorless white crystals. Used as a dietary supplement and food additive.

• Reaktivität anzeigen

  Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

• Health Hazard

  Vitamin D2 poisoning disturbs calcium metabolism and causes kidney damage. Vitamin D2 in a single acute ingestion presents no toxic hazards. Daily ingestion in excess of 5000 units/day in children or 7500 units/day in adults will produce toxic symptoms associated with hypervitaminosis D. Those with hypercalcemia are at a greater risk.

• Brandgefahr

  Shows signs of decomposition when stored for a few days at room temperature.

• Biochem/physiol Actions

  Ergocalciferol (vitamin D2) and 25-Hydroxycholecalciferol (vitamin D3) are the two form of vitamin D which are activated in vivo by hydroxylation. Vitamin D2 and D3 may be used in a wide range of studies to assess their effects on function such as immune function and calcium homeostasis.

• Sicherheitsprofil

  Poison by ingestion, intraperitoneal, intravenous, and intramuscular routes. An experimental teratogen. Human systemic effects by ingestion: anorexia, nausea or vomiting, and weight loss. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

• mögliche Exposition

  Used as a nutrient and/or dietary supplement food additive

• Erste Hilfe

  If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contactsthe skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove fromexposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing hasstopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

• Stoffwechselwegen

  Ergocalciferol (vitamin D2) is a product made by the UV irradiation of yeast ergosterol. It is a common form of vitamin D and it has very similar biological activity to that of cholecalciferol (vitamin D3) in the treatment of the vitamin D deficiency diseases (e.g. rickets). The bioactive form of this vitamin is also the 1,25-dihydroxy-derivative and this has equal antirachitic activity to that of the cholecalciferol analogue (Jones et al., 1975).

• Lager

  Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, well-ventilated area.

• Versand/Shipping

  UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials

• läuterung methode

  It is converted into its 3,5-dinitrobenzoyl ester and crystallised repeatedly from acetone. The ester is then saponified and the free vitamin is isolated. [Laughland & Phillips Anal Chem 28 817 1956, Beilstein 6 IV 4404.]

• Degradation

  It is unstable in light and air and in acidic media. It is inactivated within a few days under normal exposure conditions. This is due to oxidation and fragmentation of the triene functionality. Ergocalciferol is slightly more unstable, probably because of the additional alkene group in the side chain. One of the several degradation products of ergocalciferol has been identified as the ketone (8, shown in Scheme 1) formed by the loss of the methano-cyclohexanol function (Stewart et al., 1984).

• Toxicity evaluation

  Excess vitamin D in the form of 1,25-dihydroxycalciferol results in hypercalcemia and hypercalciuria, due to increased calcium absorption, bone demineralization, and hyperphosphatemia.

• Inkompatibilitäten

  Dust may be combustible and may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides.

• Waste disposal

  Dispose of contents and container to an approved waste disposal plant. All federal, state, and local environmental regulations must be observed. It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffeegrounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Vitamin D2 Upstream-Materialien And Downstream Produkte

9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(723)Suppliers

50-14-6, Vitamin D2 Verwandte Suche: