1,2,3,4-Diepoxybutan

Bezeichnung:1,2,3,4-Diepoxybutan

CAS-Nr1464-53-5

Englisch Name:1,3-Butadiene diepoxide

CBNumberCB0444763

SummenformelC4H6O2

Molgewicht86.09

MOL-Datei1464-53-5.mol

Synonyma

2,2'-Bioxiran

1,2,3,4-Diepoxybutan physikalisch-chemischer Eigenschaften

Schmelzpunkt	2-4 °C(lit.)
alpha	0°(neat)
Siedepunkt	56-58 °C25 mm Hg(lit.)
Dichte	1.113 g/mL at 25 °C(lit.)
Dampfdruck	25 mm Hg ( 56 °C)
Brechungsindex	n20/D 1.434(lit.)
Flammpunkt	114 °F
storage temp.	0-6°C
Wichte	1.1
Farbe	Colorless liquid
Wasserlöslichkeit	Soluble in water (1000 g/L).
Merck	14,3676
BRN	79831
CAS Datenbank	1464-53-5(CAS DataBase Reference)
IARC	(Vol. 11, Sup 7) 1987
EPA chemische Informationen	Diepoxybutane (1464-53-5)

Sicherheit

Kennzeichnung gefährlicher	T+
R-Sätze:	45-46-24/25-26-34-10
S-Sätze:	53-45-36/37/39-28-26
RIDADR	UN 3384 6.1/PG 1
WGK Germany	1
RTECS-Nr.	EJ8225000
F	8-10-18
TSCA	Yes
HazardClass	6.1
PackingGroup	II
HS Code	29109000
Giftige Stoffe Daten	1464-53-5(Hazardous Substances Data)
Toxizität	LD50 orl-rat: 78 mg/kg AMIHBC 10,61,54

Gefahreninformationscode (GHS)

1,3-Butadiene diepoxide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R46:Kann vererbbare Schäden verursachen.
R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.
R26:Sehr giftig beim Einatmen.
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Diepoxybutane is a flammable, colorless liquid. Molecular weight=86.09; Boiling point=57℃ at25℃; Freezing/Melting point=19℃; also reported at2-4℃; Flash point=44.8℃. Hazard Identification (basedon NFPA-704 M Rating System): Health 3, Flammability 0,Reactivity 0. Mixes with water.
Chemische Eigenschaften
clear colorless to very slightly yellow liquid
Verwenden
Diepoxybutane has been used as a research chemical, as a chemical intermediate, as a curing agent for polymers, as a cross-linking agent for textile fabrics, and to prevent microbial spoilage (IARC 1976, HSDB 2009). It has also been used to synthesize erythritol and pharmaceuticals (HSDB 2009). Because of its cross-linking properties, diepoxybutane is used as a test agent in the diagnosis of Fanconi anemia, which is characterized by chromosomal instability (Auerbach et al. 1989).
Verwenden
Butadiene diepoxide is used as a research chemical, as a chemical intermediate, as a curing agent for polymers, as a cross-linking agent for textile fabrics, and to prevent microbial spoilage. It is also been used to synthesize erythritol and pharmaceuticals.
Verwenden
Curing of polymers; cross-linking of textile fibers; prevention of microbial spoilage
Verwenden
1,3-Butadiene Diepoxide is used as a substance in the evaluation of anti-diabetic and anti-ulcer potential of selected fresh fruits samples and their GC/MS analysis. Also in the inhibitory potency of 4-carbon alkanes and alkenes towards CYD2E1 activity.
Definition
ChEBI: Diepoxybutane is an epoxide. It has a role as a mutagen.
Vorbereitung Methode
Diepoxybutane is prepared by chlorination of butadiene followed by epoxidation with peracetic acid, with subsequent hydrolysis of the epoxide group and final reepoxidation with caustic.
Allgemeine Beschreibung
Colorless liquid. Used in curing polymers; crosslinking textile fibers and to prevent spoilage.
Air & Water Reaktionen
Highly Flammable
Reaktivität anzeigen
Epoxides, such as 1,3-BUTADIENE DIEPOXIDE, are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts.
Hazard
Probable carcinogen; neoplastigen; tumorigenic; poison; mutagen.
Health Hazard
Severe skin and eye irritant. Accidental minor exposure caused swelling of the eyelids, upper respiratory tract irritation and painful eye irritation 6 hours after exposure.NOTE: The dl- and meso-forms (CAS Registry Numbers 298-18-0 and 564-00-1, respectively) as well as the L(-) form (CAS Registry Number 30031-64-2) have all been determined to be positive animal carcinogens.
Brandgefahr
When heated to decomposition 1,3-BUTADIENE DIEPOXIDE emits acrid smoke and irritating fumes.
Sicherheitsprofil
Confirmed carcinogen withexperimental tumorigenic data. Poison by ingestion,inhalation, skin contact, and intraperitoneal routes.Human mutation data reported. A severe skin and eyeirritant. When heated to decomposition it emits acridsmoke and irritat
mögliche Exposition
DEB is primarily used in researchand experimental work; as a curing agent for polymers; asa crosskicking agent for textile fabrics; and in preventingmicrobial spoilage in substances. DEB is also used commercially as mixed stereoisomers and as individual isomers in the preparation of erythritol and otherpharmaceuticals.
Erste Hilfe
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
Carcinogenicity
Diepoxybutane is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
Lager
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with diepoxybutane you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area. A regulated, marked area should be established where this chemical is handled, used, or stored incompliance with OSHA Standard 1910.1045.
Versand/Shipping
Toxic liquids, flammable, organic, n.o.s. requirea shipping label of “POISONOUS/TOXIC MATERIALS,FLAMMABLE LIQUID.” It falls in Hazard Class 6.1 andPacking Group I.

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