Etamivan

Bezeichnung:Etamivan

CAS-Nr304-84-7

Englisch Name:ETHAMIVAN

CBNumberCB0407636

SummenformelC12H17NO3

Molgewicht223.27

MOL-Datei304-84-7.mol

Synonyma

Etamivan

Etamivan physikalisch-chemischer Eigenschaften

Schmelzpunkt	96-97 °C
Siedepunkt	364.56°C (rough estimate)
Dichte	1.1223 (rough estimate)
Brechungsindex	1.5300 (estimate)
storage temp.	Store at -20°C
Löslichkeit	methanol: 0.1 g/mL, clear
Aggregatzustand	A solid
pka	8.73±0.20(Predicted)
Farbe	White to off-white
Merck	13,3756
CAS Datenbank	304-84-7

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	36/37/39-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	YW5250000
HazardClass	6.1(b)
PackingGroup	III
Toxizität	LD50 i.p. in rats: 28 mg/kg (Caujolle)

Gefahreninformationscode (GHS)

ETHAMIVAN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Originator
Emivan,U.S.V.,US,1961
Verwenden
antihypertensive, vasoconstrictor
Verwenden
Vanillic acid diethylamide is a central nervous system and respiratory stimulant.
Definition
ChEBI: Etamivan is phenol substituted at C-2 and C-4 by a methoxy group and an N,N-diethylaminocarbonyl group respectively. A respiratory stimulant drug related to nikethamide, it has now fallen largely into disuse. It is a member of phenols and a member of methoxybenzenes.
Manufacturing Process
4 g of vanillinic acid are mixed with 3.6 g of diethylamine, after cooling 2.2 g of phosphorus pentoxide and the same amount of glass powder are added, and then reacted with xylene until a thin paste has been formed. The latter is boiled for some hours in the reflux cooler, moisture being excluded. Decantation follows, and the residue is dissolved by means of a warm solution of potassium carbonate until only glass powder or small amount of impurities remain undissolved, and then the xylene solution is shaken up therewith, The xylene solution is then separated, the aqueous layer is again extracted with ether, and the ether extract is combined with the xylene solution. The mixture is then distilled under the lowest possible pressure, collecting the fraction between 170°C and 250°C (referred to 10 Torr), and purifying it by further fractionation. In this way a slightly yellowish oil is obtained, which crystallizes after some time. By dissolving in ligroin and crystallizing, pure vanillinic acid diethylamide is obtained in the form of white needles; MP 95°C to 95.5°C.
Trademarks
Vandid (3M Pharmaceuticals).
Therapeutic Function
Central and respiratory stimulant
Weltgesundheitsorganisation (WHO)
Etamivan is a central and respiratory stimulant.

ETHAMIVAN Upstream-Materialien And Downstream Produkte

Etamivan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

304-84-7, ETHAMIVAN Verwandte Suche:

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