17β-Hydroxyestr-4-en-3-on-17-decanoat

Bezeichnung:17β-Hydroxyestr-4-en-3-on-17-decanoat

CAS-Nr360-70-3

Englisch Name:Nandrolone Decanoate

CBNumberCB0396051

SummenformelC28H44O3

Molgewicht428.65

MOL-Datei360-70-3.mol

Synonyma

17β-Hydroxyestr-4-en-3-on-17-decanoat

17β-Hydroxyestr-4-en-3-on-17-decanoat physikalisch-chemischer Eigenschaften

Schmelzpunkt	33-37°C
alpha	32 º
Siedepunkt	483.46°C (rough estimate)
Dichte	1.0406 (rough estimate)
Brechungsindex	1.4700 (estimate)
storage temp.	2-8°C
Löslichkeit	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL
Aggregatzustand	powder
Farbe	white to light yellow
Wasserlöslichkeit	664ug/L(37 ºC)
InChIKey	JKWKMORAXJQQSR-MOPIKTETSA-N
SMILES	[C@@]12([H])CC[C@H](OC(=O)CCCCCCCCC)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3CC[C@@]21[H] \|&1:0,4,17,21,23,33,r\|
CAS Datenbank	360-70-3

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	40
S-Sätze:	22-36
WGK Germany	3
RTECS-Nr.	KG7967000
HS Code	2937290000
Toxizität	LD50 intraperitoneal in mouse: > 566mg/kg

Gefahreninformationscode (GHS)

Nandrolone Decanoate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Nandrolone decanoate, also known as nandrolone caprinate, is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis. The process for creating esters of [nandrolone] was patented in Spain in 1959 and in 1960, it was described as having a long duration of action and strong anabolic effect compared to nandrolone and other esters. Nandrolone decanoate was granted FDA approval on 5 October 1962.
Chemische Eigenschaften
White or almost white, crystalline powder.
Originator
Deca-Durabolin,Organon,US,1962
Verwenden
Nandrolone Decanoate is an anabolic steroid. Nandrolone decanoate is used in the treatment of osteoporosis in postmenopausal women. Nandrolone Decanoate is also used for some aplastic anemias. Control led Substance.
Definition
ChEBI: Nandrolone decanoate is a steroid ester.
Manufacturing Process
1 gram of 19-nortestosterone is dissolved in 3 ml of dry pyridine, after which the resulting solution is cooled to -20°C. A solution of 1.0 gram of decanoic acid chloride in 3 ml of dry benzene is added to the cooled solution. The mixture is maintained at -15°C for 16 hours and then poured into ice water. The aqueous liquid is extracted with benzene, the benzene solution is washed with respectively 1 N sodium hydroxide solution, 2 N hydrochloric acid and with water until neutral reaction.
Then the solution is dried on sodium sulfate, filtered, and evaporated to dryness. The residue, 1.63 grams is dissolved in hexane, this solution is filtered over 30 grams of neutral aluminum oxide, and evaporated to dryness. On paper chromatographic investigation it turned out that the obtained 19- nortestosterone 17-decanoate which at room temperature is an oil consists of a single compound, according to US Patent 2,998,423.
Trademarks
Durabolin (Organon);Abolon;Activin;Anabolin la 100;Anador;Anadur;Analone-50;Androlone d 100;Androlone d 50;Decabolin;Deca-durabolin decanoate;Deca-noralone;Docabolin;Fherbolico;Fortabolin;Hybolin-decanoate;Iebolan;Kabolin;Keratyl;Methybol-depot;Nandrolone decanoate;Nordecon;Stenabolin;Sterobolin;Turinabol-depot.
Therapeutic Function
Anabolic
Weltgesundheitsorganisation (WHO)
Nandrolone decanoate, an anabolic steroid, was introduced in 1962. In 1982, low dosage preparations were prohibited in Bangladesh due to inadmissible promotion of products containing anabolic steroids for malnourished children. Higher dosage preparations of nandrolone decanoate remain available in many countries, including Bangladesh, for several highly specific but limited indications that apply to patients with chronic debilitating and emaciating diseases, particularly associated with neoplasia and some types of aplastic anaemia.
Allgemeine Beschreibung
Nandrolone decanoate,17β-hydroxyestr-4-en-3-one 17-decanoate, has been used inthe management of certain anemias, but the availability oferythropoietin has greatly reduced this use.
Biochem/physiol Actions
Compared to testosterone propionate, nandrolone decanoate is considered to have strong anabolic effects but weak androgenic effects (potency ratios of 3.29–4.92 and 0.31–0.41). In particular, nandrolone esters are thought to have the highest ratio of anabolic to androgenic effects of any AAS. The low androgenicity of nandrolone decanoate is thought to be due to the fact that nandrolone is inactivated by 5α-reductase via transformation into the low-affinity androgen receptor (AR) ligand 5α-dihydronandrolone. This is thought to result in a lower incidence and magnitude of side effects.Nandrolone decanoate (ND) injection has been classified as a Schedule III controlled substance under the Anabolic Steroids Control Act of 1990. Due to serious health risks, the nonmedical use of AASs is banned by most sports organizations[1].
Nebenwirkungen
There are many effects of this drug on the human body, and the studies of its side effects can be divided into the following: categories endocrine, cardiovascular, skin, psychiatric, musculoskeletal, excretory, and gastrointestinal disorders.

The most common side effects were: endocrine disorders (virilization, gynecomastia, hormonal disorders, cholesterol and lipid disorders, genital and infertility issues); cardiovascular disorders (vascular damage, coagulation disorders, arteriosus hypertension); skin disorders (pricking, acne, skin spots); psychiatric disorders (aggressiveness, mood disorders, sleep disorders, anxiety); musculoskeletal disorders (tendon ruptures); excretory disorders (organ damage); gastrointestinal disorders (organ damage and liver adenomas); neurological disorders (seizures); immune disorders (chronic infection relapse; respiratory disorders (sleep apnea syndrome); genetic disorders (genetic damage)[1].
Sicherheitsprofil
Experimental reproductiveeffects. When heated to decomposition it emits acridsmoke and irritating fumes.
Veterinary Drugs and Treatments
The principle use of nandrolone in veterinary medicine has been to stimulate erythropoiesis in patients with certain anemias (e.g., secondary to renal failure, aplastic anemias). It has also been suggested for use as an appetite stimulant.

Nandrolone Decanoate Upstream-Materialien And Downstream Produkte

17β-Hydroxyestr-4-en-3-on-17-decanoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

360-70-3, Nandrolone Decanoate Verwandte Suche:

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