α-[1-(tert-Butylamino)ethyl]-2,5-dimethoxybenzylalkoholhydrochlorid

Bezeichnung:α-[1-(tert-Butylamino)ethyl]-2,5-dimethoxybenzylalkoholhydrochlorid

CAS-Nr5696-15-1

Englisch Name:Butoxamine hydrochloride

CBNumberCB0392437

SummenformelC15H26ClNO3

Molgewicht303.82

MOL-Datei5696-15-1.mol

Synonyma

α-[1-(tert-Butylamino)ethyl]-2,5-dimethoxybenzylalkoholhydrochlorid

α-[1-(tert-Butylamino)ethyl]-2,5-dimethoxybenzylalkoholhydrochlorid physikalisch-chemischer Eigenschaften

Aggregatzustand	Solid
Farbe	White to off-white

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36
S-Sätze:	26
WGK Germany	3

Gefahreninformationscode (GHS)

Butoxamine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Originator
Butoxamine,SigmaAldrich
Verwenden
Antidiabetic; antihyperlipoproteinemic.
Verwenden
Butoxamine Hydrochloride is a beta-2 selective beta blocker. β2-adrenergic receptor(AR) antagonist; Antiarrhythmic;
Manufacturing Process
548.0 g (2 mol) of 2,5-dimethoxy-α-bromopropiophenone was dissolved in 500 ml of acetanitrile and 365.0 g (5 mol) of t-butylamine was added. The solution was allowed to stand at room temperature for 64 h and was then diluted with 2 L of anhydrous ether. The precipitated t-butylamine hydrobromide was filtered off and washed with ether. The filtrate and washings were concentrated in vacuo using a water-bath kept at 40°C. When most of the solvent had been removed, the residual material was dissolve in cold methanol and acidified with hydrochloric acid. The solution was then taken down to dryness in vacuo on the steam bath and the 1-(2,5- dimethoxyphenyl)-2-(t-butylamino)propiophenone was obtained, melting point 175-176°C (recrystallised from an ethanol ether mixture).
The bulk of the 1-(2,5-dimethoxyphenyl)-2-(t-butylamino)propiophenone was dissolved in methanol and hydrogenated over platinum (Adams' catalyst). After removal of the catalyst, the solvent was removed in vacuo and the residual solid was dissolved in water and the solution was washed with ether.
The aqueous layer was basified (dilute sodium hydroxide solution) and the base was taken into ether. After drying over anhydrous potassium carbonate, the ether was evaporated and the base was distille at 0.3 mm pressure. So the DL-erythro 1-(2,5-dimethoxyphenyl)-2-(t-butylamino)propanol, boiling point 127-128°C was obtained.
Therapeutic Function
Oral hypoglycemic, Antihyperlipidemic

Butoxamine hydrochloride Upstream-Materialien And Downstream Produkte

α-[1-(tert-Butylamino)ethyl]-2,5-dimethoxybenzylalkoholhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5696-15-1, Butoxamine hydrochloride Verwandte Suche:

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