3-(Chlormethyl)pyridin-hydrochlorid

Bezeichnung:3-(Chlormethyl)pyridin-hydrochlorid

CAS-Nr6959-48-4

Englisch Name:3-Picolyl chloride hydrochloride

CBNumberCB0374970

SummenformelC6H7Cl2N

Molgewicht164.03

MOL-Datei6959-48-4.mol

Synonyma

3-(Chlormethyl)pyridiniumchlorid

3-(Chlormethyl)pyridin-hydrochlorid

3-(Chlormethyl)pyridin-hydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	137-143 °C(lit.)
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	Soluble[in water]
Aggregatzustand	Crystalline Needles or Powder
Farbe	White to beige
Wasserlöslichkeit	>=10 g/100 mL at 19 ºC
Sensitive	Hygroscopic
BRN	3689156
InChI	InChI=1S/C6H6ClN.ClH/c7-4-6-2-1-3-8-5-6;/h1-3,5H,4H2;1H
InChIKey	UZGLOGCJCWBBIV-UHFFFAOYSA-N
SMILES	C1(CCl)C=NC=CC=1.Cl
CAS Datenbank	6959-48-4(CAS DataBase Reference)
EPA chemische Informationen	3-(Chloromethyl)pyridine hydrochloride (6959-48-4)

Sicherheit

Kennzeichnung gefährlicher	Xn,C,T
R-Sätze:	22-36/37/38-45-20/21/22-34
S-Sätze:	26-36-53-45-36/37/39
RIDADR	2811
WGK Germany	3
RTECS-Nr.	US7000000
F	3-10
Hazard Note	Corrosive
HazardClass	8
PackingGroup	III
HS Code	29333999
Giftige Stoffe Daten	6959-48-4(Hazardous Substances Data)

Gefahreninformationscode (GHS)

3-Picolyl chloride hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R45:Kann Krebs erzeugen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White to pale brown solid
Verwenden
3-(Chloromethyl)pyridine Hydrochloride has been used as a reactant for the synthesis of (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-one derivatives as Polo-like kinase 4 (PLK4) inhibitors.
Application
3-Picolyl chloride hydrochloride is an organic synthetic reagent for the preparation of N,N-bis(pyridin-2-ylmethyl)aniline ligands, 2-oxodihydroquinoline-3-carboxamide derivatives, and 3β-amino-tropane arylamide derivatives with atypical antipsychotic profiles. It is also used in the preparation of novel bifunctional anion exchange resins for nuclear waste treatment.
Allgemeine Beschreibung
Yellow powder or yellow-tan solid with an irritating odor.
Air & Water Reaktionen
Hygroscopic. Water soluble.
Reaktivität anzeigen
3-Picolyl chloride hydrochloride is incompatible with strong oxidizing agents and strong bases.
Brandgefahr
Flash point data for 3-Picolyl chloride hydrochloride are not available; however, 3-Picolyl chloride hydrochloride is probably combustible.
Sicherheitsprofil
Suspected carcinogen with experimental carcinogenic data. Poison by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and Cl-.
Synthese
Chloromethyl pyridine hydrochloride is the important industrial chemicals of various agricultural chemicals, medicine intermediate, Insecticides (tech) & Herbicides (tech), sterilant. A synthetic method of 3-(chloromethyl)pyridine hydrochloride (also known as 3-Picolyl chloride hydrochloride) comprises steps as follows: (1) 3-methylpyridine is taken as a raw material, water is taken as a solvent, and the 3-methylpyridine is oxidized into 3-picolinic acid with potassium permanganate, wherein the molar ratio of the 3-methylpyridine to the potassium permanganate is 1:(2.1-2.3), the oxidizing temperature is kept at 85-90 DEG C, heating is performed for 30 min, a reaction solution is adjusted to be acid after the reaction, and 3-picolinic acid is obtained after cooling and filtration; (2) the 3-picolinic acid and methanol react to produce methyl pyridine-3-carboxylate under the acid condition, and the molar ratio of the 3-picolinic acid to the methanol is 1:1.3; (3) the methyl pyridine-3-carboxylate is reduced to 3-pyridinemethanol; (4) the 3-pyridinemethanol reacts with thionyl chloride to produce a target product, namely, 3-(chloromethyl)pyridine hydrochloride, and the molar ratio of the 3-pyridinemethanol to the thionyl chloride is 1:(1.1-1.3).

3-Picolyl chloride hydrochloride Upstream-Materialien And Downstream Produkte

3-(Chlormethyl)pyridin-hydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

6959-48-4, 3-Picolyl chloride hydrochloride Verwandte Suche:

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