Cholest-5-en-3β-ylhydrogensuccinat

Bezeichnung:Cholest-5-en-3β-ylhydrogensuccinat

CAS-Nr1510-21-0

Englisch Name:Cholesteryl hemisuccinate

CBNumberCB0336321

SummenformelC31H50O4

Molgewicht486.73

MOL-Datei1510-21-0.mol

Synonyma

Cholest-5-en-3β-ylhydrogensuccinat

Cholest-5-en-3β-ylhydrogensuccinat physikalisch-chemischer Eigenschaften

Schmelzpunkt	178 °C
Siedepunkt	586.0±43.0 °C(Predicted)
Dichte	1.06±0.1 g/cm3(Predicted)
Brechungsindex	-34 ° (C=2, CHCl3)
storage temp.	-20°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
Aggregatzustand	Solid
pka	4.40±0.17(Predicted)
Farbe	White to Off-White
InChIKey	WLNARFZDISHUGS-BLYFUZNHSA-N
LogP	10.708 (est)
CAS Datenbank	1510-21-0(CAS DataBase Reference)

Sicherheit

WGK Germany	3
HS Code	29171900

Cholesteryl hemisuccinate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Cholesteryl hemisuccinate is a cholesterol ester with anticancer activity. It inhibits the growth of murine C1498 myeloid and L1210 lymphocytic leukemia cells when used at concentrations of 50 and 150 μM, respectively. Cholesteryl hemisuccinate acts as an ionizable anionic detergent and is commonly used to stabilize unilamellar vesicles and liposomes. It has also been used as an emulsifying agent in various vesicular drug delivery systems for anticancer drugs, antibiotics, and oligonucleotides and to solubilize various proteins including chemokine receptor 1 as well as erythrocyte ghosts.
Verwenden
Cholesteryl Hemisuccinate is an oxidation product of polyunsaturated fatty acid of cholesterol that alters lysosome structure and functions and induces proinflammatory cytokine production in macrophages.
Definition
ChEBI: Cholesteryl hemisuccinate is a dicarboxylic acid monoester resulting from the formal condensation of the hydroxy group of cholesterol with one of the carboxy groups of succinic acid. A detergent that is often used to replace cholesterol in protein crystallography, biochemical studies of proteins, and pharmacology. It has a role as a detergent. It is a cholestane ester, a dicarboxylic acid monoester and a hemisuccinate. It is functionally related to a cholesterol.
Allgemeine Beschreibung
Cholesteryl hemisuccinate (CHEMS) is an acidic cholesterol ester.
Biochem/physiol Actions
CHEMS can help to maintain the stability of dioleoylphosphatidylethanolamine (DOPE). This amphipathic lipid is used in mixtures with dioleoylphosphatidylethanolamine (DOPE) to form ′pH sensitive′ fusogenic vesicles. It can control cell growth.

Cholesteryl hemisuccinate Upstream-Materialien And Downstream Produkte

Cholest-5-en-3β-ylhydrogensuccinat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1510-21-0, Cholesteryl hemisuccinate Verwandte Suche:

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