N-Acetyl-β-D-glucosamin

Bezeichnung:N-Acetyl-β-D-glucosamin

CAS-Nr7512-17-6

Englisch Name:N-Acetyl-D-Glucosamine

CBNumberCB0320700

SummenformelC8H15NO6

Molgewicht221.21

MOL-Datei7512-17-6.mol

Synonyma

N-Acetyl-β-D-glucosamin

N-Acetyl-β-D-glucosamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	211 °C (dec.) (lit.)
alpha	42 º (c=2,water,2 hrs)
Dampfdruck	8Pa at 20℃
Brechungsindex	+39.0 to +42.0 ° (C=1, H2O)
storage temp.	-20°C
Löslichkeit	Soluble in concentrated hydrochloric acid, sulfuric acid, phosphoric acid and formic acid. Insoluble in water, dilute acids, dilute alkalis, concentrated alkalis and organic solvents.
Aggregatzustand	saline suspension
Siedepunkt	636.4±55.0 °C(Predicted)
Dichte	1.54 g/cm3
pka	13.04±0.20(Predicted)
Farbe	white to off-white
Optische Aktivität	Alpha type +75 → +41 Beta type -22 → +41.3
Wasserlöslichkeit	H2O: 50 mg/mL colorless to faint yellow solution, clear to very slightly hazy
Sensitive	Hygroscopic
Merck	14,4458
BRN	1727589
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	OVRNDRQMDRJTHS-ROGOILFBSA-N
LogP	-2.2 at 23.7℃
CAS Datenbank	7512-17-6(CAS DataBase Reference)
EPA chemische Informationen	N-Acetylglucosamine (7512-17-6)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	24/25-36-26-22
WGK Germany	3
RTECS-Nr.	LZ6651000
F	3-10
Hazard Note	Irritant
TSCA	Yes
HS Code	29329985

Gefahreninformationscode (GHS)

N-Acetyl-D-Glucosamine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
N-Acetyl-D-Glucosamine is the N-acetyl derivative of glucosamine.Chemically it is an amide between glucosamine and acetic acid. A single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins -O-GlcNAc, is an ubiquitous post-translational protein modification. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. In humans, it exists in skin, cartilage and blood vessel as a component of hyaluronic acid, and bone tissue, cornea and aorta as a component of keratan sulfate.
N-Acetyl-D-glucosamine (D-GlcNAc) is a derivitized glucose monomer found in polymers of bacterial cell walls, chitin, hyaluronic acids and various glycans. It is also synthesized in the glycosylation pathway as uridine diphosphate (UDP-GlcNAc), which can then be released following degradation of glycosylated proteins.D-GlcNAc is used to identify, differentiate and characterize N-acetyl-β-D-hexoaminidase(s). It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.
Chemische Eigenschaften
White powder
Verwenden
N-Acetyl-D-glucosamine is used in the identification and characterization of N-acetyl-beta-D-hexoaminidase. It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.
Verwenden
N-acetyl-D-Glucosamine (GlcNAc) is a monosaccharide derivative of glucose. It is released by the action of O-GlcNAcase, in mammalian systems from proteins that have been post-translationally modified with O-GlcNAc.D-GlcNAc enhances the proliferation and collagen expression of fibroblasts, reduces hyperpigmentation and is therefore considered a valuable ingredient in cosmetics for improving skin wrinkles and color.Important substrate for the production of sialic acids.Used in multiple other applications in drug development and food supplement, based on a newly described bio-wave model.
Definition
ChEBI: N-acetyl-D-glucosamine is the D isomer of N-acetylglucosamine. It has a role as a bacterial metabolite. It is a N-acetylglucosamine and a N-acetyl-D-hexosamine.
Allgemeine Beschreibung
N-Acetyl-D-glucosamine (GlcNAc) is a monosaccharide, derived from glucose and undergoes linear polymerization by (1,4)-β-linkages to form the polymer chitin. It is also a component of heterogenous polysaccharides, such as murein and hyaluronic acid. N-acetylglucosamine exhibits anti-inflammatory properties and is considered as a potential drug in the treatment of osteoarthritis. Its antiarthritic mode of mechanism involves the suppression of IL-1β (Interleuken-1β)-induced NO (nitric oxide), cyclooxygenase-2 (COX-2), and IL-6 production by inhibition of expression of iNOS (inducible nitric oxide synthase) protein and mRNA.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
N-Acetyl-D-glucosamine (GlcNAc) oligomer may have the ability to initiate factors for canine polymorphonuclear cells (PMN) in vivo. It possesses wound healing and chemotactic activity. GlcNAc and its derivatives are usually employed in preparing dietary supplements and also used in therapeutic development.

N-Acetyl-D-Glucosamine Upstream-Materialien And Downstream Produkte

N-Acetyl-β-D-glucosamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

7512-17-6, N-Acetyl-D-Glucosamine Verwandte Suche:

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