NERIDRONATE SODIUM HYDRATE

Bezeichnung:NERIDRONATE SODIUM HYDRATE

CAS-Nr79778-41-9

Englisch Name:NERIDRONATE SODIUM HYDRATE

CBNumberCB0261270

SummenformelC6H17NO7P2

Molgewicht277.15

MOL-Datei79778-41-9.mol

NERIDRONATE SODIUM HYDRATE physikalisch-chemischer Eigenschaften

Schmelzpunkt	245°
Siedepunkt	600.1±65.0 °C(Predicted)
Dichte	1.658±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	H₂O: 8 mg/mL, soluble
Aggregatzustand	solid
pka	1.93±0.10(Predicted)
Farbe	white

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
WGK Germany	3

Gefahreninformationscode (GHS)

NERIDRONATE SODIUM HYDRATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
Beschreibung
Neridronic acid was launched in Italy as intravenous or intramuscular injection for the treatment of osteogenesis imperfecta. It is the first drug launched worldwide for this “orphan disease” characterized by a fragility of the bone. Sufferers risk frequent fractures commencing during infancy, eventually leading to bone deformation and a severe deterioration of the quality of life and life expectancy. Neridronic acid is structurally related to the second generation of bisphosphonates characterized by an amino terminal group and can be synthesized by treating E-aminocaproic acid with phosphoric acid and phosphorous trichloride. Bisphosphonates, synthetic analogs of the endogenous mineral deposition inhibitor pyrophosphate, are extremely potent inhibitors of bone resorption and increase bone mineral density, possibly by inhibiting the activity of osteoclasts and promoting the death of these bone-eroding cells. In vitro, neridronic acid was a poor inhibitor of phagocytosis, but significantly and dose dependently inhibited 8glucuronidase release and superoxide anion production in the rat peritoneal macrophage, two parameters that may have a part in bone resorption. In a clinical study on patients with osteogenesis imperfecta, neridronic acid increased remarkably bone mass in young growing individuals. In adults the changes were less important but still significant.
Beschreibung
Neridronic acid is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC₅₀ = 388.2 nM in a cell-free assay). It decreases the differentiation of RAW 264.7 cells into osteoclasts in a CRL-12257 co-culture model of osteoclastogenesis when used at concentrations ranging from 0.001 to 100 μM. Neridronic acid (30 μM) inhibits FGF2-induced proliferation and tube formation in human umbilical vein endothelial cells (HUVECs). It reduces the loss of trabeculae and increases bone density in the tibial metaphysis of growing rats when administered subcutaneously at a dose of 0.1 mg/kg per day.
Originator
lnstituto Gentili (Italy)
Definition
ChEBI: Neridronic acid is a 1,1-bis(phosphonic acid).
Trademarks
Nerixia
Biochem/physiol Actions
Neridronate is a bone resorption inhibitor. It is used to treat Osteogenesis Imperfecta, an "orphan disease" characterized by a fragility of the bone enough to be named the "illness of bones of crystal".
Synthese
6- Aminohexanoic acid (152) was reacted with phosphorus trichloride and phosphorous acid at 85??C, and then water was added to generate free diphosphonic acid 16 in 78% overall yield [59].

NERIDRONATE SODIUM HYDRATE Upstream-Materialien And Downstream Produkte

NERIDRONATE SODIUM HYDRATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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