Sulconazle Nitrate Struktur

Sulconazle Nitrate

Bezeichnung:Sulconazle Nitrate

CAS-Nr82382-23-8

Englisch Name:Sulconazle Nitrate

CBNumberCB02131212

SummenformelC18H15Cl3N2S.HNO3

Molgewicht460.76

MOL-Datei82382-23-8.mol

Sulconazle Nitrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	148-153°C
storage temp.	Refrigerator
Löslichkeit	Acetonitrile (Slightly, Heated), Methanol (Slightly), Water (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
CAS Datenbank	82382-23-8

Sulconazle Nitrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Sulconazole nitrate is an imidazole antifungal agent closely related to econazole. It is effective in the topical treatment of a broad spectrum of superficial fungal infections.
Originator
Syntex (USA)
Verwenden
Antifungal.
Definition
ChEBI: Sulconazole nitrate is an organic nitrate salt, a conazole antifungal drug and an imidazole antifungal drug.
Trademarks
Exelderm (Westwood-Squibb).
Biologische Aktivität
Sulconazole Nitrate is an imidazole derivative with broad-spectrum antifungal activity.
Clinical Use
1-[2,4-Dichloro-β-[p-chlorobenzyl)thio]phenethyl]imidazolemononitrate (Exelderm) is the white crystalline nitricacid salt of sulconazole. It is sparingly soluble in water butsoluble in ethanol. The salt is used in a solution and a cream in 1% concentration for the treatment of local tinea infections,such as jock itch, athlete’s foot, and ringworm.
in vitro
Sulconazole Nitrate possesses a broad spectrum of activity in vitro against dermatophytes, yeasts and some Gram-positive bacteria at concentrations below 5 mg/L in vitro. It has been shown that against representatives of pathogenic yeasts, dermatophytes and Aspergilli, the RIF values of sulconazole are broadly similar to those of other imidazoles. The fungicidal potency of sulconazole in vitro depends on its concentration and on the growth phase of the inoculum cells. Sulconazole has also demonstrated antibacterial activity in vitro, with MIC values below 12.5 mg/L.
in vivo
The efficacy and safety of sulconazole 1% cream has been demonstrated in controlled clinical studies in patients with superficial dermatophyte or yeast infections. To minimise the risk of reinfection treatment should continue for 3 weeks in Candida infections, tinea cruris, tinea corporis and pityriasis versicolor, and for 4 weeks in patients with tinea pedis.

Sulconazle Nitrate Upstream-Materialien And Downstream Produkte

Sulconazle Nitrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

82382-23-8, Sulconazle Nitrate Verwandte Suche:

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