1-[2-(2,4-Dichlorphenyl)-2-[(2,6-dichlorphenyl)methoxy]ethyl]-1H-imidazoliumnitrat

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P273：Freisetzung in die Umwelt vermeiden.

  P391：Verschüttete Mengen aufnehmen.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Isoconazole nitrate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  White Solid

• Originator

  Fazol,Fournier,France,1979

• Verwenden

  Antibacterial; antifungal

• Verwenden

  Isoconazole Nitrate acts as an antibacterial in the local treatment of vaginitis; antifungal agent (1,2).

• Manufacturing Process

  To a stirred and refluxing solution of 40 parts of benzene and 35 parts of dimethylformamide (both solvents previously dried azeotropically) are added successively 1.6 parts of sodium hydride and 7.7 parts of α-(2,4- dichlorophenyl)imidazole-1-ethanol, (cooling on ice is necessary). After the addition is complete, stirring and refluxing is continued for 30 minutes. Then there are added 7.8 parts of 2.6-dichlorobenzyl chloride and the whole is stirred at reflux for another 3 hours. The reaction mixture is poured onto water and the product 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl] imidazole, is extracted with benzene. The extract is washed twice with water, dried, filtered and evaporated in vacuo. The base residue is dissolved in a mixture of acetone and diisopropyl ether and to this solution is added an excess of concentrated nitric acid solution. The precipitated nitrate salt is filtered off and recrystallized from a mixture of methanol and diisopropyl ether, yielding 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl]imidazole nitrate; melting point 179°C.

• Therapeutic Function

  Antibacterial, Antifungal

Isoconazole nitrate Upstream-Materialien And Downstream Produkte

1-[2-(2,4-Dichlorphenyl)-2-[(2,6-dichlorphenyl)methoxy]ethyl]-1H-imidazoliumnitrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(232)Suppliers

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