1-[2-[(4-Chlorphenyl)methoxy]-2-(2,4-dichlorphenyl)ethyl]-1H-imidazoliumnitrat Produkt Beschreibung

Econazole nitrate Struktur
24169-02-6
  • CAS-Nr.24169-02-6
  • Bezeichnung:1-[2-[(4-Chlorphenyl)methoxy]-2-(2,4-dichlorphenyl)ethyl]-1H-imidazoliumnitrat
  • Englisch Name:Econazole nitrate
  • Synonyma:1-[2-[(4-Chlorphenyl)methoxy]-2-(2,4-dichlorphenyl)ethyl]-1H-imidazoliumnitrat
    Pargin;Amicel;Micogin;Gynoryl;SQ 13050;Micofugal;e Nitrate;NSC 243115;Gyno-Pevaril;Gyno-prevaryl
  • CBNumber:CB3173103
  • Summenformel:C18H16Cl3N3O4
  • Molgewicht:444.7
  • MOL-Datei:24169-02-6.mol
1-[2-[(4-Chlorphenyl)methoxy]-2-(2,4-dichlorphenyl)ethyl]-1H-imidazoliumnitrat physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :162°C
  • storage temp.  :Inert atmosphere,Room Temperature
  • Löslichkeit :chloroform/methanol: soluble25mg/mL (choloroform:methanol (1:1))
  • Aggregatzustand :powder
  • Farbe :white to off-white
  • Wasserlöslichkeit :<0.1 g/100 mL at 19 ºC
  • Merck  :14,3502
  • InChIKey :DDXORDQKGIZAME-UHFFFAOYSA-N
  • CAS Datenbank :24169-02-6(CAS DataBase Reference)
  • EPA chemische Informationen :Econazole mononitrate (24169-02-6)
Sicherheit
  • Kennzeichnung gefährlicher :Xn,Xi
  • R-Sätze: :22-36/38-36/37/38
  • S-Sätze: :26-36-36/37
  • WGK Germany  :3
  • RTECS-Nr. :NI4450000
  • HS Code  :29332900
  • Toxizität :LD50 in mice, rats (mg/kg): 462.7, 667.7 orally (Thienpont)

Econazole nitrate Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R22:Gesundheitsschädlich beim Verschlucken.
    R36/38:Reizt die Augen und die Haut.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
    S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  • Chemische Eigenschaften White to Off-White Solid
  • Originator Pevaryl,Cilag Chemie,France,1976
  • Verwenden Econazole nitrate is an antifungal agent of the imidazole type used in topical and vaginal preparations to prevent growth of dermatophytes, yeast, and mold.
  • Verwenden Antifungal;Ergosterol synthesis inhibition
  • Verwenden Azole antifungal
  • Manufacturing Process A suspension of 10.3 parts of α-(2,4-dichlorophenyl)-imidazole-1-ethanol and 2.1 parts of sodium hydride in 50 parts of dry tetrahydrofuran is stirred andrefluxed for 2 hours. After this reaction-time, the evolution of hydrogen is ceased. Then there are added successively 60 parts dimethylformamide and 8 parts of p-chlorobenzylchloride and stirring and refluxing is continued for another two hours. The tetrahydrofuran is removed at atmospheric pressure. The dimethylformamide solution is poured onto water. The product, 1-[2,4- dichloro-β-(p-chlorobenzyloxy)phenethyl]imidazole, is extracted with benzene. The extract is washed with water, dried, filtered and evaporated in vacuo. From the residual oily free base, the nitrate salt is prepared in the usual manner in 2-propanol by treatment with concentrated nitric acid, yielding, after recrystallization of the crude solid salt from a mixture of 2-propanol, methanol and diisopropylether, 1-[2,4-dichloro-β-(pchlorobenzyloxy)phenethyl]imidazole nitrate; MP 162°C.
  • Trademarks Spectazole (Johnson & Johnson).
  • Therapeutic Function Antifungal
  • Allgemeine Beschreibung White crystalline powder.
  • Air & Water Reaktionen Insoluble in water.
  • Brandgefahr Flash point data for Econazole nitrate are not available; however, Econazole nitrate is probably combustible.
Econazole nitrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-[2-[(4-Chlorphenyl)methoxy]-2-(2,4-dichlorphenyl)ethyl]-1H-imidazoliumnitrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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24169-02-6, Econazole nitrate Verwandte Suche:
  • (RS)-1-[2,4-DICHLORO-BETA-(P-CHLOROBENZYLOXY)PHENETHYL]-IMIDAZOLE NITRATE
  • 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazolium nitrate
  • ECONAZOLE NITRATE 99%-101%
  • ECONAZOLE NITRATE
  • ECONAZOLE NITRATE SALT
  • ECONAZOL NITRATE
  • 1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)imidazole nitrate
  • 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]-1h-imidazole mononitrate
  • 1-[2-([4-CHLOROPHENYL]METHOXY)-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE NITRATE
  • 1-[2-([4-CHLOROPHENYL]METHOXY)-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE NITRATE SALT
  • 1H-Imidazole, 1-2-(4-chlorophenyl)methoxy-2-(2,4-dichlorophenyl)ethyl-, mononitrate
  • 1-[2-(4-Chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate
  • Gyno-Pevaril
  • Imidazole, 1-[2,4-dichloro-β-[(p-chlorobenzyl)oxy]phenethyl]-, mononitrate (8CI)
  • Micofugal
  • Micogin
  • NSC 243115
  • Pargin
  • SQ 13050
  • 1H-Imidazole, 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-, nitrate
  • Gyno-prevaryl
  • Amicel
  • 1-[2-(4-chlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole
  • 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
  • 1H-Imidazole, 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-, nitrate (1:1)
  • Bifonazole Solution, 100ppm
  • Econazole nitrate salt,1-(2-[(4-Chlorophenyl)methoxy]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole
  • ECONAZOLENITRATE1%
  • Econazole&nbsp
  • Econazole nitrate (Spectazole)
  • Gynoryl
  • 1-(2-((4-chlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-iMidazole nitrate
  • 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, nitrate (1:1)
  • econazole nitrate:1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)-ethyl)-1h-IMIDAZOLE mononitrate
  • Econazole nitrate, 98.5%
  • EconazoleNitrate&gt
  • e Nitrate
  • 1-(2-((2-chlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole nitrate
  • Econazole nitrate USP/EP/BP
  • 24169-02-6
  • 24169-02-6;68797-31-9
  • C18H16Cl3N3O4
  • C18H14Cl3N2OHNO3
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