Phosphatidylethanolamine

Bezeichnung:Phosphatidylethanolamine

CAS-Nr90989-93-8

Englisch Name:Phosphatidylethanolamine

CBNumberCB0198532

SummenformelC9H18NO8P

Molgewicht299.214881

MOL-Datei90989-93-8.mol

Phosphatidylethanolamine physikalisch-chemischer Eigenschaften

storage temp.	-20°C
Löslichkeit	Chloroform: Soluble
Aggregatzustand	solution
Farbe	Light yellow to yellow
InChI	InChI=1S/C9H18NO8P/c1-7(11)15-5-9(18-8(2)12)6-17-19(13,14)16-4-3-10/h9H,3-6,10H2,1-2H3,(H,13,14)
InChIKey	CFWRDBDJAOHXSH-UHFFFAOYSA-N
SMILES	P(=O)(O[H])(OC([H])([H])C([H])([H])N([H])[H])OC([H])([H])C([H])(C([H])([H])OC(C([H])([H])[H])=O)OC(C([H])([H])[H])=O
CAS Datenbank	90989-93-8

Sicherheit

Kennzeichnung gefährlicher	T,Xn
R-Sätze:	45-46-23/24/25-36/37/38-48/20/22-22-67-40-36/38-20-63
S-Sätze:	53-23-36/37/39-45-26-36/37
RIDADR	UN 2810 6.1/PG 2
WGK Germany	3
F	1-8-10

Gefahreninformationscode (GHS)

Phosphatidylethanolamine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R46:Kann vererbbare Schäden verursachen.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R48/20/22:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Einatmen und durch Verschlucken.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Phosphatidylethanolamine is also known as cerebral lecithin because of its high content in brain tissue. It coexists with lecithin in various tissues and organs of the body, and its structure and physicochemical properties are similar to those of lecithin, except that in cerebral lecithin, it is cholamine that combines with phosphoric acid. This product is a compound glycerophospholipid extracted from the brain and spinal cord of livestock. Slightly yellow amorphous powder; has a special odor. No certain melting point, with spin. Soluble in petroleum ether, chloroform, ether, and methanol, slightly soluble in benzene and carbon tetrachloride, insoluble in water. Easily hygroscopic, easily oxidized to brownish black in air. Amphoteric compound.
Verwenden
1,2-Diacyl-sn-glycero-3-phosphoethanolamine is the major structural phopholipids in brain.
Biochem/physiol Actions
The major structural phospholipid in brain, comprising 20-25% of total lipid; primarily localized to gray matter.

in vivo

Phosphatidylethanolamine (375 mg/kg; i.p.) significantly inhibits food intake and locomotor activity in mice^[4].
Phosphatidylethanolamine (2 g added to the basal diet containing 8 g of soybean oil; p.o.; dietary administration; ad libitum; 15-18 days) causes a decrease in serum cholesterol, phospholipid, apolipoprotein A-I (apoA-I) and apoE, an increase in high molecular weight apoB, alters the distribution of hepatic phospholipids and the fatty acid composition of serum and hepatic phospholipids in rats^[6].

Animal Model:	Model: Male Wistar rats (weight: 143 g, specific age not mentioned) fed cholesterol-free semipurified diet^[6]
Dosage:	2 g of Phosphatidylethanolamine added to the basal diet containing 8 g of soybean oil
Administration:	Dietary administration, ad libitum, 15-18 days
Result:	Led to a significant decrease in serum cholesteryl ester, phospholipid, apoA-I and apoE, while serum apoB was higher compared to the PC and control groups. Decreased hepatic cholesterol. Altered the relative distribution of phospholipid subclasses in the liver. Altered the fatty acid composition of liver PC and PE. Enhanced the excretion of fecal neutral steroids. Showed higher hepatic HMG-CoA reductase activity.

Phosphatidylethanolamine Upstream-Materialien And Downstream Produkte

Phosphatidylethanolamine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

90989-93-8, Phosphatidylethanolamine Verwandte Suche:

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