Alpha-D-Lactose monohydrate

Bezeichnung:Alpha-D-Lactose monohydrate

CAS-Nr5989-81-1

Englisch Name:Alpha-D-Lactose monohydrate

CBNumberCB0177832

SummenformelC12H24O12

Molgewicht360.31

MOL-Datei5989-81-1.mol

Alpha-D-Lactose monohydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	219 °C
alpha	[α]D20+52.2～+52.8°
Siedepunkt	412.35°C (rough estimate)
Dichte	1,53 g/cm³
Brechungsindex	1.6480 (estimate)
RTECS-Nr.	OD9625000
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	H2O: soluble1M, clear, colorless
Aggregatzustand	Solid
Farbe	White to Off-White
PH	pH (50g/l, 25℃) : 4.0～6.0
Biologische Quelle	bovine milk
Wasserlöslichkeit	Soluble in water.
Stabilität	Hygroscopic
InChI	1S/C12H22O11.H2O/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17;/h3-20H,1-2H2;1H2/t3-,4-,5+,6+,7-,8-,9-,10-,11+,12+;/m1./s1
InChIKey	WSVLPVUVIUVCRA-KPKNDVKVSA-N
SMILES	[H]O[H].OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
CAS Datenbank	5989-81-1(CAS DataBase Reference)
EPA chemische Informationen	.alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-, hydrate (1:1) (5989-81-1)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	40-36/37/38
S-Sätze:	24/25-36-26
WGK Germany	3
TSCA	Yes
HS Code	17021100
Speicherklasse	11 - Combustible Solids

Gefahreninformationscode (GHS)

Alpha-D-Lactose monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White powder
Chemische Eigenschaften
Lactose occurs as white to off-white crystalline particles or powder. It is odorless and slightly sweet-tasting. Spray-dried directcompression grades of lactose are generally composed of 80–90% specially prepared pure a-lactose monohydrate along with 10–20% of amorphous lactose.
Verwenden
alpha-D-Lactose monohydrate is used as a carrier and stabiliser of aromas, pharmaceutical products, Food industry.
Definition
A sugar that occurs in many plants. It is extracted commercially from sugar cane and sugar beet. Sucrose is a disaccharide formed from a glucose unit and a fructose unit. It is hydrolyzed to a mixture of fructose and glucose by the enzyme invertase. Since this mixture has a different optical rotation (levorotatory) than the original sucrose, the mixture is called invert sugar.
Vorbereitung Methode
A suspension of a-lactose monohydrate crystals in a lactose solution is atomized and dried in a spray drier. Approximately 10–20% of the total amount of lactose is in solution and the remaining 80–90% is present in the crystalline form. The spray-drying process predominantly produces spherical particles. The compactibility of the material and its flow characteristics are a function of the primary particle size of the lactose monohydrate and the amount of amorphous lactose.
Pharmazeutische Anwendungen
Spray-dried lactose is widely used as a binder, filler-binder, and flow aid in direct compression tableting.
Biochem/physiol Actions
alpha-Lactose is the primary sugar present in milk and the main energy source to a newborn mammalian through its mother′s milk. It is digested by the intestinal lactase (EC 3.2.1.108), an enzyme expressed in newborns. The enzyme′s activity declines following weaning which can lead to lactose intolerance in adult mammals.
Sicherheit(Safety)
Lactose is widely used in pharmaceutical formulations as a diluent in oral capsule and tablet formulations. It may also be used in intravenous injections.
Adverse reactions to lactose are largely due to lactose intolerance, which occurs in individuals with a deficiency of the enzyme lactase.
Lager
Spray-dried lactose should be stored in a well-closed container in a cool, dry place.
Inkompatibilitäten
Lactose is a reducing sugar. The amorphous lactose, which is the most reactive form of lactose present in spray-dried lactose, will interact more readily than conventional crystalline grades. Typical reactions include the Maillard reaction with either primary or secondary amines.

Alpha-D-Lactose monohydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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