4-Fluoro-2-methylphenol

Bezeichnung:4-Fluoro-2-methylphenol

CAS-Nr452-72-2

Englisch Name:4-Fluoro-2-methylphenol

CBNumberCB0136772

SummenformelC7H7FO

Molgewicht126.13

MOL-Datei452-72-2.mol

4-Fluoro-2-methylphenol physikalisch-chemischer Eigenschaften

Schmelzpunkt	37-38 °C (lit.)
Siedepunkt	87 °C/14 mmHg (lit.)
Dichte	1.1514 (estimate)
Brechungsindex	1.5155-1.5175
Flammpunkt	185 °F
storage temp.	Inert atmosphere,Room Temperature
pka	10.32±0.18(Predicted)
Aggregatzustand	Low Melting Solid or Liquid
Farbe	Off-white to brownish
Wasserlöslichkeit	Insoluble in water.
BRN	2041490
Major Application	environmental
InChI	InChI=1S/C7H7FO/c1-5-4-6(8)2-3-7(5)9/h2-4,9H,1H3
InChIKey	GKQDDKKGDIVDAG-UHFFFAOYSA-N
SMILES	C1(O)=CC=C(F)C=C1C
CAS Datenbank	452-72-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-21/22
S-Sätze:	26-36/37/39
RIDADR	UN 1325 4.1/PG 2
WGK Germany	3
Hazard Note	Irritant
HazardClass	8
HS Code	29081990
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

4-Fluoro-2-methylphenol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R21/22:Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Off-white to brownish low melting solid or liquid
Verwenden
4-Fluoro-2-methylphenol is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.
Allgemeine Beschreibung
Laccase mediated grafting of 4-fluoro-2-methylphenol with lignin model compound, dibenzodioxocin and lignocellulose material has been investigated.
Synthese
Add 70g of water and 26g of concentrated sulfuric acid to the 250mL reaction flask (pay attention to exothermic, add concentrated sulfuric acid to water slowly, the same below), add 17.5g of 4-fluoro-2-methylaniline at room temperature while stirring, a white solid was produced, raise the temperature to 100~105 , completely dissolved, and reduce the temperature to 0 ; slowly add 44.5g of nitrosyl sulfuric acid dropwise, control the temperature at -5~5 , hold the heat after dropwise The reaction solution was clarified for 2h to obtain the diazo solution. In another 250mL reaction bottle add 66g of water and 19g of concentrated sulfuric acid, warming to 110 , drop into the above prepared diazo liquid, control the drop acceleration, drop and add the side of water vapor distillation, so that the oil droplets continue to evaporate, the temperature is controlled at 110 ~ 115 ; drop and add the completion of the distillation continued for 2 hours, until no oil droplets evaporated; separation of the oil layer, add 11.1g content of 1% aqueous sodium hydroxide solution to wash, and the oil layer, the top temperature of 80 , and then the oil layer, the top temperature is 0 , the top temperature of 80 , the top temperature is 0 . Separate the oil layer, the top temperature of 80 ~ 90 _x000D _ 10mmHg distillation, the product 4-fluoro-2-methylphenol 14.8g, GC: 99.5%, yield 83%.
Einzelnachweise
[1] Tetrahedron Letters, 2011, vol. 52, # 41, p. 5338 - 5341

4-Fluoro-2-methylphenol Upstream-Materialien And Downstream Produkte

4-Fluoro-2-methylphenol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

452-72-2, 4-Fluoro-2-methylphenol Verwandte Suche:

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