雄酮
- CAS号:53-41-8
- 英文名:Androsterone
- 中文名:雄酮
- CBNumber:CB9853748
- 分子式:C19H30O2
- 分子量:290.44
- MOL File:53-41-8.mol
- 熔点 :181-184 °C(lit.)
- 沸点 :372.52°C (rough estimate)
- 比旋光度 :96 º (c=1, C2H5OH)
- 密度 :1.0320 (rough estimate)
- 折射率 :1.4709 (estimate)
- 储存条件 :−20°C
- 溶解度 :Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
- 酸度系数(pKa) :15.14±0.60(Predicted)
- 水溶解性 :11.5mg/L(23.5 ºC)
- Merck :13,645
- BRN :2217626
- CAS 数据库 :53-41-8(CAS DataBase Reference)
- NIST化学物质信息 :Androsterone(53-41-8)
- EPA化学物质信息 :Androsterone (53-41-8)
- 危险品标志 :Xi
- 危险类别码 :36/37/38-43
- 安全说明 :22-24/25-36/37-26
- WGK Germany :3
- RTECS号 :BV8053000
- F :3-21
- 海关编码 :29379000
雄酮 MSDS
Androstan-3a-ol-17-one
雄酮性质、用途与生产工艺
- 睾酮代谢物 雄酮 androsterone，即3α-羟-5d-雄烷-17-酮。是由男性尿中检出的睾酮代谢物之一。是以葡糖醛酸抱合体的形式而排出于尿中。其雄性激素作用弱于睾酮。表雄酮（epian-drosterone）是在3β位上有羟基的异构物。
- 生物活性 Androsterone (5alpha-Androsterone)是源于性激素的类固醇代谢产物，具有较弱的雄激素属性。
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靶点
Human Endogenous Metabolite
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体外研究
Androsterone activates both the mFXR-LBD and the hFXR-LBD, with Androsterone activating the mFXR-LBD more strongly than the hFXR-LBD. Furthermore, cotransfection studies with gal4-hFXR-LBD and SRC-1/VP16 expression plasmids demonstrate that Androsterone potentiates the interaction of SRC-1 with the hFXR-LBD. Several amino acid changes including H294S, S332V, R351H, and Y361F significantly reduce Androsterone activation. Androsterone (5α, 3α-A) (10 to 100 μM) also inhibits epileptiform discharges in a concentration-dependent fashion in the in vitro slice model.
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体内研究
Androsterone treatment results in a significant induction of small heterodimer partner (SHP), suggesting Androsterone may activate endogenous FXR. Intraperitoneal injection of Androsterone (5α, 3α-A) protects mice in a dose-dependent fashion from seizures in the following models (ED 50 , dose in mg/kg protecting 50% of animals): 6 Hz electrical stimulation (29.1), pentylenetetrazol (43.5), pilocarpine (105), 4-AP (215), and maximal electroshock (224).
- 更新日期：2024/11/11
- 产品编号：XW00534183
- 产品名称：雄酮
- CAS编号：53-41-8
- 包装：1G
- 价格：306元
- 更新日期：2024/11/11
- 产品编号：XW00534182
- 产品名称：雄酮
- CAS编号：53-41-8
- 包装：5G
- 价格：1045元
- 公司名称：BUJNO Synthesis Sp. z o. o.
- 联系电话：--
- 电子邮件：synthesis@bujno.com.pl
- 国家：波兰
- 产品数：264
- 优势度：38
