53-41-8
基本信息
雄(甾)酮
雄甾酮,雄酮,雄性酮
3α-羟基-5α-雄甾烷-17-酮
雄甾酮
5Α-雄烷-3Α-醇-17-酮
男酯酮
顺式酮基化甾醇
顺式雄素酮
顺式雄酮
雄性酮
3ALPHA-HYDROXY-5ALPHA-ANDROSTAN-17-ONE
3-ALPHA-HYDROXYETIOALLOCHOLAN-17-ONE
5A-ANDROSTAN-3A-OL-17-ONE
5ALPHA-ANDROSTAN-3ALPHA-OL-17-ONE
5ALPHA-ANDROSTAN-3ALPHA-OL-17-ONE-16,16-D2
androstan-3a-ol-17-one
ANDROSTERINE
ANDROSTEROLONE
ANDROSTERONE
CIS-ANDROSTERONE
3-alpha-hydroxy-17-androstanone
3alpha-Hydroxy-17-androstanone
3-alpha-hydroxy-5-alpha-androstan-17-on
3-Epihydroxyetioallocholan-17-one
3-hydroxy-,(3-alpha,5-alpha)-androstan-17-on
3-hydroxy-,(3alpha,5alpha)-androstan-17-on
5alpha-Androstan-17-one, 3alpha-hydroxy-
5alpha-Androstane-3alpha-ol-17-one
5alpha-Androsterone
物理化学性质
| 外观性质 | 白色或类白色结晶性粉末。溶于醇, 不溶于水。熔点：181-184℃ |
| 熔点 | 181-184 °C(lit.) |
| 比旋光度 | 96 º (c=1, C2H5OH) |
| 沸点 | 372.52°C (rough estimate) |
| 密度 | 1.0320 (rough estimate) |
| 折射率 | 1.4709 (estimate) |
| 储存条件 | −20°C |
| 溶解度 | Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml |
| 酸度系数(pKa) | 15.14±0.60(Predicted) |
| 形态 | neat |
| 水溶解性 | 11.5mg/L(23.5 ºC) |
| Merck | 13,645 |
| BRN | 2217626 |
| 主要应用 | pharmaceutical (small molecule) |
| InChI | 1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 |
| InChIKey | QGXBDMJGAMFCBF-HLUDHZFRSA-N |
| SMILES | [H][C@@]12CC[C@@]3([H])[C@]4([H])CCC(=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@H](O)C2 |
| CAS 数据库 | 53-41-8(CAS DataBase Reference) |
| NIST化学物质信息 | Androsterone(53-41-8) |
| EPA化学物质信息 | Androsterone (53-41-8) |
安全数据
| 危险性符号(GHS) |  GHS08 |
| 警示词 | 危险 |
| 危险性描述 | H351-H360FD |
| 防范说明 | P201-P202-P280-P308+P313-P405-P501 |
| 危险品标志 | Xi |
| 危险类别码 | 36/37/38-43 |
| 安全说明 | S22-S24/25 |
| WGK Germany | 3 |
| RTECS号 | BV8053000 |
| F | 3-21 |
| 海关编码 | 29379000 |
| 存储类别 | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| 危险性类别 | Carc. 2 Repr. 1B |
应用领域
常见问题列表
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Human Endogenous Metabolite
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Androsterone activates both the mFXR-LBD and the hFXR-LBD, with Androsterone activating the mFXR-LBD more strongly than the hFXR-LBD. Furthermore, cotransfection studies with gal4-hFXR-LBD and SRC-1/VP16 expression plasmids demonstrate that Androsterone potentiates the interaction of SRC-1 with the hFXR-LBD. Several amino acid changes including H294S, S332V, R351H, and Y361F significantly reduce Androsterone activation. Androsterone (5α, 3α-A) (10 to 100 μM) also inhibits epileptiform discharges in a concentration-dependent fashion in the in vitro slice model.
Androsterone treatment results in a significant induction of small heterodimer partner (SHP), suggesting Androsterone may activate endogenous FXR. Intraperitoneal injection of Androsterone (5α, 3α-A) protects mice in a dose-dependent fashion from seizures in the following models (ED 50 , dose in mg/kg protecting 50% of animals): 6 Hz electrical stimulation (29.1), pentylenetetrazol (43.5), pilocarpine (105), 4-AP (215), and maximal electroshock (224).
图谱信息
雄酮(53-41-8)质谱(MS)雄酮(53-41-8)核磁图(1HNMR)雄酮(53-41-8)核磁图(13CNMR)雄酮(53-41-8)红外图谱(IR1)雄酮(53-41-8)红外图谱(IR2)知名试剂公司产品信息
Androsterone, 97%(53-41-8) Acros Organics
Androsterone,>96.0%(GC)(53-41-8) TCI Shanghai
雄酮价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | XW00534183 | 雄酮 | 53-41-8 | 1G | 306元 |
| 2025/05/22 | XW00534182 | 雄酮 | 53-41-8 | 5G | 1045元 |
| 2025/05/22 | XW00534181 | 雄酮 | 53-41-8 | 25G | 3796元 |