(S)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸
- CAS号:53174-06-4
- 英文名:(S)-(-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
- 中文名:(S)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸
- CBNumber:CB9670068
- 分子式:C14H18O4
- 分子量:250.29
- MOL File:53174-06-4.mol
- 熔点 :160 °C (dec.) (lit.)
- 沸点 :450.3±45.0 °C(Predicted)
- 密度 :1.219±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Acetonitrile (Slightly), Chloroform (Slightly, Sonicated), Methanol (Slightly)
- 酸度系数(pKa) :3.35±0.20(Predicted)
- 形态 :Solid
- 颜色 :White to Pale Beige
- 旋光性 (optical activity) :[α]26/D 65°, c = 1.2 in ethanol
(S)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸性质、用途与生产工艺
- 生物活性 (S)-Trolox 是维生素 E 的类似物，其中的植酸基链被羧基取代。(S)-Trolox 经常用作研究结构特征的模型化合物，以及作为评估抗氧化剂活性的标准。(S)-Trolox 具有有效而特定的神经保护和抗氧化作用。
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体外研究
The neuroprotective efficacy of antioxidant molecules against iodoacetate (IAA) neurotoxicity in rat cerebellar granule cell (CGC) cultures is investigated. In the absence of MK-801, (S)-Trolox displays marginal neuroprotective effects. In the presence of MK-801 (10 μM), the neuroprotective efficacy of (S)-Trolox is greatly enhanced, giving rise to a recovery in MTT-reductase activity equivalent to 80–100% of control cultures. (S)-Trolox displays EC50 value of 78 μM. The fluorescence increase in IAA-stimulated DCFH-DA-loaded cultures is inhibited in a dose-dependent manner by the antioxidants (S)-Trolox with an IC50 value of 97 μM. The antioxidant (S)-Trolox demonstrate apotent and specific neuroprotective action in an in vitro model of neurodegeneration induced by inhibition of the glycolytic enzyme GAPDH.
- 用途 色满具有α-生育酚手性中心。
- 公司名称：SIGMA
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- 国家：瑞士
- 产品数：6896
- 优势度：91
