(S)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸
(S)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸
(S)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 性质
| 熔点 | 160 °C (dec.) (lit.) |
|---|---|
| 沸点 | 450.3±45.0 °C(Predicted) |
| 密度 | 1.219±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 乙腈（少量溶解）、氯仿（少量，超声处理）、甲醇（少量溶解） |
| 酸度系数(pKa) | 3.35±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至浅棕色 |
| 旋光度 (Optical Rotation) | [α]26/D 65°, c = 1.2 in ethanol |
| InChI | 1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)/t14-/m0/s1 |
| InChIKey | GLEVLJDDWXEYCO-AWEZNQCLSA-N |
| SMILES | Cc1c(C)c2O[C@@](C)(CCc2c(C)c1O)C(O)=O |
(S)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 用途与合成方法
The neuroprotective efficacy of antioxidant molecules against iodoacetate (IAA) neurotoxicity in rat cerebellar granule cell (CGC) cultures is investigated. In the absence of MK-801, (S)-Trolox displays marginal neuroprotective effects. In the presence of MK-801 (10 μM), the neuroprotective efficacy of (S)-Trolox is greatly enhanced, giving rise to a recovery in MTT-reductase activity equivalent to 80–100% of control cultures. (S)-Trolox displays EC50 value of 78 μM. The fluorescence increase in IAA-stimulated DCFH-DA-loaded cultures is inhibited in a dose-dependent manner by the antioxidants (S)-Trolox with an IC50 value of 97 μM. The antioxidant (S)-Trolox demonstrate apotent and specific neuroprotective action in an in vitro model of neurodegeneration induced by inhibition of the glycolytic enzyme GAPDH.
安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-37/39 |
| WGK Germany | 3 |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 眼部刺激 类别2 经皮刺激 类别2 特异性靶器官毒性-一次接触，类别3 |
(S)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-05 | HY-101445B | (S)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 | 53174-06-4 | 50 mg | 500 |
| 2026-06-05 | HY-101445B | (S)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 | 53174-06-4 | 10 mM * 1 mL in DMSO | 550 |
