20(s)-原人参三醇

生物活性靶点体外研究 20(s)-原人参三醇试剂级价格

20(s)-原人参三醇

CAS号:34080-08-5
英文名:PROTOPANAXTRIOL
中文名:20(s)-原人参三醇
CBNumber:CB9511866
分子式:C30H52O4
分子量:476.74
MOL File:34080-08-5.mol

20(s)-原人参三醇化学性质

熔点 :242-244 °C
沸点 :590.0±50.0 °C(Predicted)
密度 :1.079
储存条件 :-20°C Freezer
溶解度 :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
形态 :Solid
酸度系数(pKa) :14.73±0.70(Predicted)
颜色 :Off-White
LogP :5.890 (est)

安全信息

WGK Germany :3
海关编码 :29061990

20(s)-原人参三醇性质、用途与生产工艺

生物活性 (20S)-Protopanaxatriol (g-PPT, 20(S)-APPT)是人参皂苷中具有神经保护活性的代谢物。它是糖皮质激素受体GR和雌激素受体ERbeta的功能性配体，可调节内皮细胞功能。
靶点

Glucocorticoid receptor, Oestrogen receptor, LXRα
体外研究

(20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and oestrogen receptor (ER) in human umbilical vein endothelial cells (HUVECs). (20S)-Protopanaxatriol (g-PPT) increases [Ca ²⁺ ] _i with an EC ₅₀ of 482 nM in HUVECs. (20S)-Protopanaxatriol (1 µM) elevates NO production via ERβ. (20S)-Protopanaxatriol (PPT) inhibits the autonomous transactivation of Gal4-LXRα LBD, the T0901317-dependent transcription of SREBP-1c and its promoter. (20S)-Protopanaxatriol (10 μg/mL) blocks the recruitment of RNA polymerase II to the LXRE region of SREBP-1c. (20S)-Protopanaxatriol also inhibits T0901317-dependent transcription of LXRα target genes related to lipogenesis, and reduces T0901317-induced cellular triglyceride (TG) accumulation in primary hepatocytes, but does not alter transcription of ABCA1, also an LXRα target gene.
化学性质白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参。
用途用于含量测定/鉴定/药理实验等。
药理药效:原人参三醇型皂苷可以体外协同抗原负载诱导小鼠骨髓细胞的树突状细胞成熟，发挥对肿瘤细胞的特异细胞毒作用；其次，PPT型皂苷注射液能明显改善大脑中动脉阻塞(MCAO)大鼠的偏瘫体征、缩小脑内梗死面积、缓解脑水肿症状。
用途 (20S)-原人参三醇是人参皂苷的代谢产物。