理化性质 生物活性 靶点 体外研究 体内研究 人参皂甙 Rh1 试剂级价格
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人参皂甙 Rh1

人参皂甙 Rh1,63223-86-9,结构式
人参皂甙 Rh1
  • CAS号:63223-86-9
  • 英文名:Ginsenoside Rh1
  • 中文名:人参皂甙 Rh1
  • CBNumber:CB1152803
  • 分子式:C36H62O9
  • 分子量:638.88
  • MOL File:63223-86-9.mol
人参皂甙 Rh1化学性质
  • 沸点 :755.1±60.0 °C(Predicted)
  • 密度 :1.23
  • 储存条件 :2-8°C
  • 溶解度 :DMSO : 100 mg/mL (156.53 mM; Need ultrasonic)
  • 形态 :powder
  • 酸度系数(pKa) :12.91±0.70(Predicted)
  • 颜色 :White
  • LogP :3.740 (est)

人参皂甙 Rh1性质、用途与生产工艺

  • 理化性质 人参皂苷Rh1来源为五加科植物人参Panax ginseng C. A. Mey.的干燥根,是一种白色粉末状物质,溶解性:易溶于水、甲醇、乙醇,不溶于乙/醚、苯。
  • 生物活性 20(S)-Ginsenoside Rh1 (Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1)是从红参中提取的主要生物活性化合物之一,在世界范围内,红参已越来越多地用于增强认知和身体健康。它具有抗发炎、抗氧化、免疫调节作用和对神经系统有积极作用的有效特性。20(S)-Ginsenoside Rh1 可抑制 PPAR-γ、TNF-α、IL-6 和 IL-1β 的表达。
  • 靶点

    PPAR-γ

    TNF-α

    IL-6

    IL-1β

    Human Endogenous Metabolite

  • 体外研究

    The effect of Ginsenoside Rh1 is examined on adipogenesis in 3T3-L1 cells. Ginsenoside Rh1 potently inhibits the adipogenesis, as assessed by Oil-red O staining and lipid contents in 3T3-L1 adipocytes. Ginsenoside Rh1, at concentrations of 50 μM and 100 μM, inhibit the adipogenesis by 50% and 63%, respectively.The expression levels of adipocytespecific genes such as PPAR-γ, C/EBP-α, FAS, aFABP and some genes are examined during early phase of differentiation such as Pref-1, C/EBP-δ and Glucocorticoid receptor (GR). After the treatment with Ginsenoside Rh1 in 3T3-L1 cells, mRNA is extracted on 18 h and 24 h for Pref-1, C/EBP-δ and GR and day 8 for PPAR-γ, C/EBP-α, FAS, aFABP. Then, the expression profiles of adipocyte-specific genes are investigated by RT-PCR. PPAR-γ, C/EBP-α, FAS, and aFABP expressions are significantly increased in DMI-stimulated differentiated adipocyte compared to those of non-stimulated adipocyte cells. However, treatment with DMI in the presence of Ginsenoside Rh1 significantly suppresses the expression levels of PPAR-γ, C/EBP-α, FAS, and aFABP in a dose- dependent manner, whereas the expression levels of Pref-1, C/EBP-δ and GR are not affected.

  • 体内研究

    When high-fat diet (HFD) fed mice for 8 weeks, body and epididymal fat weight gains are significantly increased compared to those of low-fat diet (LFD)-fed mice. However, when Ginsenoside Rh1 is treated in HFD-fed mice, body and epididymal fat weight gains are significantly decrease compared with those of the HFD-fed mice. TG, glucose, insulin, total cholesterol, and HDL levels in the blood are significantly increased in HFD-fed mice group compared to LFD-fed mice group. Treatment with Ginsenoside Rh1 in HFD-fed mice significantly lowers TG level alone.

  • 化学性质  白色粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于人参。
  • 用途  用于含量测定/鉴定/药理实验等。
    药理药效:具有滋补强壮,抗肿瘤作用。
  • 用途  (20S)-人参皂苷Rh1是人参中的主要成分之一,具有抗炎作用。
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人参皂甙 Rh1 试剂级价格
  • 更新日期:2024/01/25
  • 产品编号:HY-N0604
  • 产品名称:人参皂甙 Rh1 Ginsenoside Rh1
  • CAS编号:63223-86-9
  • 包装:5mg
  • 价格:400元
  • 更新日期:2024/01/25
  • 产品编号:HY-N0604
  • 产品名称:人参皂甙 Rh1 Ginsenoside Rh1
  • CAS编号:63223-86-9
  • 包装:10mM * 1mLin DMSO
  • 价格:560元
人参皂甙 Rh1生产厂家
  • 公司名称:山东西亚化学有限公司
  • 联系电话:4009903999 13355009207
  • 电子邮件:3007715519@qq.com
  • 国家:中国
  • 产品数:18736
  • 优势度:57
  • 公司名称:化夏化学
  • 联系电话:400-1166-196 18981987031
  • 电子邮件:cdhxsj@163.com
  • 国家:中国
  • 产品数:11726
  • 优势度:57
  • 公司名称:艾科试剂
  • 联系电话:4008-755-333 18080918076
  • 电子邮件:800078821@qq.com
  • 国家:中国
  • 产品数:9725
  • 优势度:55
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