罗红霉素钙盐(链霉菌属载体)
- CAS号:56092-82-1
- 英文名:IONOMYCIN CALCIUM SALT
- 中文名:罗红霉素钙盐(链霉菌属载体)
- CBNumber:CB9458893
- 分子式:C41H70CaO9
- 分子量:747.07
- MOL File:56092-82-1.mol
- 熔点 :205-206 C
- 闪点 :87 °C
- 储存条件 :−20°C
- 溶解度 :Soluble in DMSO (10mg/ml). Also soluble in ethanol or methanol
- 形态 :White to off-white solid
- 颜色 :white to off-white
- 生物来源 :Streptomyces conglobatus
- 敏感性 :Light Sensitive
- BRN :1416163
- 稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
罗红霉素钙盐(链霉菌属载体)性质、用途与生产工艺
- 生物活性 Ionomycin calcium (SQ23377 calcium) 是一种有效的，选择性的钙离子载体 (calcium ionophore)，也是一种由 Streptomyces conglobatus 产生的抗生素。Ionomycin calcium (SQ23377 calcium) 对二价阳离子具有高度特异性 (Ca>Mg>Sr=Ba)。Ionomycin (SQ23377) 促进细胞凋亡。Ionomycin calcium (SQ23377 calcium) 还诱导蛋白激酶C (PKC) 激活。
-
靶点
Calcium ionophore
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体外研究
Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus .
Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca 2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment.
Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment.
- 更新日期：2025/02/08
- 产品编号：HY-13434A
- 产品名称：罗红霉素钙盐(链霉菌属载体) Ionomycin calcium
- CAS编号：56092-82-1
- 包装：1 mg
- 价格：2380元
- 更新日期：2025/02/08
- 产品编号：HY-13434A
- 产品名称：罗红霉素钙盐(链霉菌属载体) Ionomycin calcium
- CAS编号：56092-82-1
- 包装：5mg
- 价格：5950元
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
- 公司名称：ALEXIS
- 联系电话：--
- 电子邮件：alexis-ch@alexis-corp.ch
- 国家：瑞士
- 产品数：3599
- 优势度：74
